Histopathological alterations in the prostates of Mongolian gerbils exposed to a high-fat diet and di-n-butyl phthalate individually or in combination

Author(s)

de Jesus, Mariana Marcielo ^[1] ; Negrin, Ana Carolina ^[1] ; Taboga, Sebastiao Roberto ^{[1, 2]} ; Pinto-Fochi, Maria Etelvina ^[2] ; Goes, Rejane Maira ^{[1, 2]}

Affiliation

^[1] Univ Estadual Campinas, UNICAMP, Inst Biol, Dept Funct & Struct Biol, Campinas, SP - Brazil

^[2] Univ Estadual Paulista, Dept Biol, Inst Biosci Humanities & Exact Sci, BR-15054000 Sao Jose Do Rio Preto, SP - Brazil

• Document type: Journal article
• Source: REPRODUCTIVE TOXICOLOGY; v. 52, p. 26-39, APR 2015.
• Web of Science Citations: 9

Abstract

Both high-fat diet and exposure to endocrine-disrupting chemicals have been implicated in susceptibility to pathological prostate lesions, but the consequences of combining the two have not yet been examined. We evaluated the effects of gestational and postnatal exposure to a high-fat diet (20% fat) and low doses of di-n-butyl phthalate (DBP; 5 mg/kg/day), individually or in combination, on the tissue response and incidence of pathological lesions in the ventral prostate of adult gerbils. Continuous intake of a high-fat diet caused dyslipidemia, hypertrophy, and promoted the development of inflammatory, premalignant and malignant prostate lesions, even in the absence of obesity. Life-time DBP exposure was obesogenic and dyslipidemic and increased the incidence of premalignant prostate lesions. Combined exposure to DBP and a high-fat diet also caused prostate hypertrophy, but the effects were less severe than those of individual treatments; combined exposure neither induced an inflammatory response nor altered serum lipid content. (C) 2015 Elsevier Inc. All rights reserved. (AU)

• FAPESP's process: 09/16071-9 - EFFECTS OF MATERNAL OBESITY AND POSTNATAL OVERNUTRITION ON MALE GENITAL SYSTEM OF RATS: MORPHOFUNCTIONAL EVALUATION OF LEYDIG CELL
• Grantee: Maria Etelvina Pinto Fochi
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 11/16406-0 - Combined effects of exposure to di-n-butyl phthalate and the obesogenic environment on the testicular struture and function of gerbil adult
• Grantee: Ana Carolina Negrin
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 11/01612-4 - Effects of maternal obesity and postnatal overnutrition on male genital system of rats: morphofunctional evaluation of Leydig cell
• Grantee: Rejane Maira Góes
• Support Opportunities: Regular Research Grants
• FAPESP's process: 11/16316-1 - Combined effects of exposure to di-n-butyl phtalate and obesogenic environment on the prostatic response of adult gerbils
• Grantee: Mariana Marcielo de Jesus
• Support Opportunities: Scholarships in Brazil - Master