Evaluation of Glaucomatous Damage via Functional Magnetic Resonance Imaging, and Correlations Thereof with Anatomical and Psychophysical Ocular Findings

Author(s)

Gerente, Vanessa M. ^{[1, 2]} ; Schor, Ruth R. ^{[1, 2]} ; Chaim, Khallil T. ^[1] ; Felix, Marcelo de Maria ^[1] ; Ventura, Dora F. ^[3] ; Teixeira, Sergio H. ^[2] ; Lottenberg, Claudio L. ^[1] ; Amaro, Jr., Edson ^[1] ; Paranhos, Jr., Augusto ^{[1, 2]}

Affiliation

^[1] Hosp Israelita Albert Einstein, Sao Paulo - Brazil

^[2] Univ Fed Sao Paulo, Dept Ophthalmol, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Inst Psychol, Dept Expt Psychol, Sao Paulo - Brazil

• Document type: Journal article
• Source: PLoS One; v. 10, n. 5 MAY 13 2015.
• Web of Science Citations: 5

Abstract

Purpose To evaluate the functional magnetic resonance imaging (fMRI) response to binocular visual stimulation and the association thereof with structural ocular findings and psychophysical test results in patients with glaucoma, and controls. Methods Cross-sectional study. Participants underwent a complete ophthalmic examination, including Humphrey 24-2 visual field (VF) testing and optical coherence tomography. Binocular VF in each quadrant was determined using an integrated method. Patients with glaucoma were assigned to three subgroups: initial, asymmetrical and severe glaucoma. Regions of interest (ROIs) were determined anatomically. fMRI (3 T) was performed using a bilaterally presented polar angle stimulus, and the accompanying changes in blood oxygen level-dependent (BOLD) signals were obtained from the occipital poles and calcarine ROIs. We used generalized estimation equation models to compare anatomical and functional data between the groups. Results A total of 25 subjects were enrolled, of whom 17 had glaucoma and 8 were controls. Significant associations between quadrant binocular VF sensitivities and fMRI responses were found in the occipital pole ROIs (p = 0.033) and the calcarine ROIs (p = 0.045). In glaucoma severity subgroup analysis, retinal nerve fiber layer (RNFL) thickness was associated with the BOLD response of the calcarine and occipital pole ROIs (p = 0.002 and 0.026, respectively). The initial and asymmetrical glaucoma subgroups had similar binocular VF sensitivities and RNFL thicknesses, but distinct BOLD responses. Conclusions The response of the visual cortex to binocular stimulation was associated with binocular VF sensitivity. RNFL thickness was associated with the BOLD response of the calcarine and occipital pole ROIs. (AU)

• FAPESP's process: 07/07339-2 - Evaluation of the glaucomatous lesion on the central nervous system by fMRI and the correlation with psychophysics and an atomics retinal findings
• Grantee: Augusto Paranhos Junior
• Support Opportunities: Regular Research Grants