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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Potential of Peptide-Based Enhancers for Transdermal Delivery

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Author(s):
Lopes, Luciana B. [1, 2] ; Carvalho, Vanessa F. M. [1] ; de Lemos, Debora P. [1]
Total Authors: 3
Affiliation:
[1] Univ Sao Paulo, Inst Biomed Sci, Sao Paulo, SP - Brazil
[2] Albany Coll Pharm & Hlth Sci, Albany, NY - USA
Total Affiliations: 2
Document type: Journal article
Source: CURRENT PHARMACEUTICAL DESIGN; v. 21, n. 20, p. 2814-2822, 2015.
Web of Science Citations: 5
Abstract

The skin presents several advantages as an administration route, including the possibility of localizing drugs in the tissue and overcoming the first-pass effect. However, its use is limited by the barrier function of the tissue, which is provided mainly (but not exclusively) by the stratum corneum. Various strategies to overcome this layer, have been considered over the years, ranging from the use of physical methods such as iontophoresis to well-known conventional chemical penetration enhancers like oleic acid and DMSO. However, delivery of hydrophilic and large compounds remains a challenge. More recently, selected groups of peptides have attracted increasing attention due to their ability to penetrate into the skin promoting the transport of small and large molecules, including nanodispersed systems. Here, we will discuss the properties and application to cutaneous (into the skin) and transdermal (across the skin) delivery of three groups of peptides, namely protein-transduction domains, phage-displayed peptides and antimicrobial peptides. (AU)

FAPESP's process: 13/16617-7 - Nanostructured systems for topical delivery and co-localization of chemopreventive and chemoterapeutic agents in the skin and breast tissue
Grantee:Luciana Biagini Lopes
Support Opportunities: Research Grants - Young Investigators Grants