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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Total synthesis and stereochemical assignment of cryptolatifolione

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Author(s):
Novaes, Luiz F. T. [1] ; Sarotti, Ariel M. [2] ; Pilli, Ronaldo A. [1]
Total Authors: 3
Affiliation:
[1] Univ Estadual Campinas, UNICAMP, Inst Quim, Dept Quim Organ, BR-13084971 Campinas, SP - Brazil
[2] Univ Nacl Rosario, CONICET, Fac Ciencias Bioquim & Farmaceut, Inst Quim Rosario, RA-2000 Rosario, Santa Fe - Argentina
Total Affiliations: 2
Document type: Journal article
Source: RSC ADVANCES; v. 5, n. 66, p. 53471-53476, 2015.
Web of Science Citations: 6
Abstract

An enantioselective total synthesis of cryptolatifolione and its C-8 epimer is presented in a protecting-group-free fashion. The synthesis relied on the use of a catalytic double Krische allylation, catalytic olefin metathesis and a C-H oxidation. Comparison of spectroscopic data of the synthetic isomers and natural product made possible the unambiguous elucidation of the absolute configuration of cryptolatifolione. (AU)

FAPESP's process: 09/51602-5 - Chemical biology: new natural and synthetic molecular targets against cancer, structural studies, biological evaluation and mode of action
Grantee:Ronaldo Aloise Pilli
Support Opportunities: Research Projects - Thematic Grants