| Full text | |
| Author(s): |
Shamim, Anwar
[1]
;
Souza, Frederico B.
[2]
;
Trossini, Gustavo H. G.
[2]
;
Gatti, Fernando M.
[2]
;
Stefani, Helio A.
[2]
Total Authors: 5
|
| Affiliation: | [1] Univ Sao Paulo, Inst Quim, Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Farm, Sao Paulo, SP - Brazil
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | MOLECULAR DIVERSITY; v. 19, n. 3, p. 423-434, AUG 2015. |
| Web of Science Citations: | 5 |
| Abstract | |
We have developed an efficient, CuI-catalyzed, microwave-assisted method for the synthesis of bis-1,2,3-triazole derivatives starting from a 3,4,6-tri--acetyl-d-glucal-derived mesylate. This mesylate was obtained from 3,4,6-tri--acetyl-d-glucal through -glycosidation, deprotection of acetate groups to alcohols, and selective mesylation of the primary alcohol. This mesylate moiety was then converted to an azide through a microwave-assisted method with good yield. The azide, once synthesized, was then treated with different terminal alkynes in the presence of CuI to synthesize various bis-triazoles in high yields and short reaction times. (AU) | |
| FAPESP's process: | 13/20553-4 - Synthesis and functionalization of vinyl iodide sulfoxides |
| Grantee: | Frederico Bernardes de Souza |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |
| FAPESP's process: | 12/00424-2 - Synthesis of small libraries using potassium Organotrifluoroborates in Suzuki-Miyaura reactions |
| Grantee: | Helio Alexandre Stefani |
| Support Opportunities: | Research Projects - Thematic Grants |