Coproduction of KPC-2 and IMP-10 in Carbapenem- Resistant Serratia marcescens Isolates from an Outbreak in a Brazilian Teaching Hospital

Author(s)

Silva, Kesia Esther ^[1] ; Cayo, Rodrigo ^[2] ; Carvalhaes, Cecilia Godoy ^[2] ; Correia Sacchi, Flavia Patussi ^[3] ; Rodrigues-Costa, Fernanda ^[2] ; Ramos da Silva, Ana Carolina ^[2] ; Croda, Julio ^{[1, 3, 4]} ; Gales, Ana Cristina ^[2] ; Simionatto, Simone ^[1]

Affiliation

^[1] UFGD, Lab Pesquisa Ciencias Saude, Dourados, MS - Brazil

^[2] Univ Fed Sao Paulo, Dept Med, Lab ALERTA, Disciplina Infectol, Sao Paulo - Brazil

^[3] UFGD, Hosp Univ Dourados, Dourados, MS - Brazil

^[4] Fundacao Osvaldo Cruz, Campo Grande, MS - Brazil

• Document type: Journal article
• Source: Journal of Clinical Microbiology; v. 53, n. 7, p. 2324-2328, JUL 2015.
• Web of Science Citations: 13

Abstract

We describe an outbreak caused by KPC-2- and IMP-10-producing Serratia marcescens isolates in a Brazilian teaching hospital. Tigecycline was the only active antimicrobial agent tested. The bla(IMP-10) gene was located in a new class 1 integron, named In990, carried by a nonconjugative plasmid, in contrast to bla(KPC-2). (AU)

• FAPESP's process: 12/15459-6 - Contribution of the penicillin-binding proteins (PBPs) to beta-lactam resistance in Acinetobacter baumannii strains isolated from different Brazilian Regions
• Grantee: Rodrigo Cayô da Silva
• Support Opportunities: Scholarships in Brazil - Post-Doctoral