Effects of prenatal immune activation on amphetamine-induced addictive behaviors: Contributions from animal models

Author(s):Show less -

Borcoi, Aline R. ^[1] ; Patti, Camilla L. ^[1] ; Zanin, Karina A. ^{[1, 2]} ; Hollais, Andre W. ^[1] ; Santos-Baldaia, Renan ^[1] ; Ceccon, Liliane M. B. ^[1] ; Berro, Lais F. ^{[1, 2]} ; Wuo-Silva, Raphael ^[1] ; Grapiglia, Stephanie B. ^[1] ; Ribeiro, Luciana T. C. ^[1] ; Lopes-Silva, Leonardo B. ^{[1, 2]} ; Frussa-Filho, Roberto ^[1]

Affiliation

^[1] Univ Fed Sao Paulo, Dept Farmacol, BR-04023062 Sao Paulo, SP - Brazil

^[2] Univ Fed Sao Paulo, Dept Psicobiol, BR-04021002 Sao Paulo, SP - Brazil

• Document type: Journal article
• Source: PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY; v. 63, p. 63-69, DEC 3 2015.
• Web of Science Citations: 6

Abstract

Background: Prenatal environmental adversities may affect brain development and are associated with increased risk for schizophrenia, an illness with 50% comorbidity with addiction. Maternal immune activation by polyinosinic-citidilic acid (Poly(I:C)) exposure can promote behavioral alterations consistent with schizophrenia symptoms in rodents. Objectives: Considering the vulnerability to addiction in patients with schizophrenia, we evaluated the interactions between prenatal Poly(I:C) administration and addiction in two animal models (behavioral sensitization and conditioned place preference - CPP) in mice repeatedly treated with amphetamine (AMP). Additionally, stereotyped behavior and cross-sensitization with cocaine (COC) were also investigated. Methods: Swiss male mice offspring were submitted to prenatal administration of 5 mg/kg Poly(I: C) in the 9th day of pregnancy. At the age of 90 days, mice were treated with 2.5 mg/kg AMP for 9 days to evaluate behavioral sensitization or stereotyped behavior. Cross-sensitization with 10 mg/kg COC was evaluated 24 h after the last treatment day. For AMP-induced CPP evaluation, mice were treated during 8 consecutive days. Results: Prenatal Poly(I:C) administration potentiated both AMP-induced behavioral sensitization and CPP. Furthermore, Poly(I:C) increased cross-sensitization with COC. Conclusions: Prenatal administration of Poly(I:C) is able to potentiate vulnerability to addiction in two animal models, without however modulating stereotyped behavior. (C) 2015 Elsevier Inc. All rights reserved. (AU)

• FAPESP's process: 10/20200-6 - Effects of repeated administration of Zolpidem on memory phases in mice submitted to experimental insomnia
• Grantee: Karina Agustini Zanin
• Support Opportunities: Scholarships in Brazil - Doctorate