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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Post-allogeneic Hematopoietic Stem Cell Transplantation (HSCT) changes in inorganic salivary components

Full text
Author(s):
Boer, C. C. [1] ; Correa, M. E. P. [1] ; Tenuta, L. M. A. [2] ; Souza, C. A. [1] ; Vigorito, A. C. [1]
Total Authors: 5
Affiliation:
[1] Univ Estadual Campinas, Hematol & Blood Transfus Ctr, BR-13083878 Campinas, SP - Brazil
[2] Univ Campinas UNICAMP, Piracicaba Dent Sch, Dept Physiol Sci, Piracicaba, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: SUPPORTIVE CARE IN CANCER; v. 23, n. 9, p. 2561-2567, SEP 2015.
Web of Science Citations: 2
Abstract

Recent studies have considered the qualitative and quantitative assessment of salivary flow, as well the biochemical components of saliva, as possible biomarkers that might contribute to the pathogenesis of chronic graft-versus-host disease (cGHVD) in hematopoietic stem cell transplantation (HSCT) patients. The aim of this study was to evaluate prospectively the inorganic salivary status at different periods of allogeneic HSCT. Saliva collection and oral examination were performed prior to the HSCT, aEuro < between days 8 and 10, days 80 and 100, and at the cGVHD onset. Concentrations of calcium (Ca), phosphate (Pi), chloride (Cl), magnesium (Mg), potassium (K), and sodium (Na) were performed using colorimetric reactions and atomic absorption. Fifty-five consecutive patients undergoing first allogeneic HSCT were included in this study. Between days 8 and 10, the salivary flow rate was significantly higher (p = 0.05), Pi concentration was decreased (p = 0.007), and Na and Cl were increased (p = 0.001 and p = 0.001, respectively), compared with the baseline. Salivary flow rate during the same period showed a negative correlation with Pi concentration (p = 0.02) and a positive correlation with Na and Cl concentrations (p = 0.003 and p = 0.001, respectively). The salivary flow rate was decreased between days 80 and 100 (p = 0.02) and Na, Cl, and K concentrations were increased (p = 0.03, p = 0.02, and p = 0.003, respectively). Salivary flow rate showed a negative correlation with Na and Cl (p = 0.01 and p = 0.013, respectively). At cGVHD onset, the salivary flow rate showed no statistical difference compared with the other studied periods. A trend was observed in the higher Na concentration compared with the baseline (p = 0.06) and Pi concentration presented a significant decrease (p = 0.004). Ca and Mg concentrations showed no changes during all evaluation periods. The present study showed changes in inorganic salivary components in post-HSCT periods, mainly during the early period post-HSCT and at the cGVHD onset. We speculate that Na, Cl, and Pi in saliva could be used as a potential biomarker in further studies. (AU)

FAPESP's process: 11/00165-4 - Prospective evaluation of regulatories T cells activities in oral mucosal and minor salivary glands and analysis of salivary composition from patients submmited to allogeneic steam cell transplantation.
Grantee:Camila Cominato Boer
Support Opportunities: Scholarships in Brazil - Doctorate