| Full text | |
| Author(s): |
Porta, Alberto
[1, 2]
;
Faes, Luca
[3, 4]
;
Nollo, Giandomenico
[3, 4]
;
Bari, Vlasta
[1]
;
Marchi, Andrea
[5]
;
De Maria, Beatrice
[6]
;
Takahashi, Anielle C. M.
[7]
;
Catai, Aparecida M.
[7]
Total Authors: 8
|
| Affiliation: | [1] IRCCS Policlin San Donato, Dept Cardiothorac Vasc Anesthesia & Intens Care, Milan - Italy
[2] Univ Milan, Dept Biomed Sci Hlth, Milan - Italy
[3] Univ Trento, Dept Ind Engn, BIOtech, Trento - Italy
[4] IRCS PAT FBK, Trento - Italy
[5] Politecn Milan, Dept Elect Informat & Bioengn, I-20133 Milan - Italy
[6] IRCCS Fdn Salvatore Maugeri, Dept Rehabil Med, Milan - Italy
[7] Univ Fed Sao Carlos, Dept Physiotherapy, BR-13560 Sao Carlos, SP - Brazil
Total Affiliations: 7
|
| Document type: | Journal article |
| Source: | PLoS One; v. 10, n. 7 JUL 15 2015. |
| Web of Science Citations: | 25 |
| Abstract | |
Self-entropy (SE) and transfer entropy (TE) are widely utilized in biomedical signal processing to assess the information stored into a system and transferred from a source to a destination respectively. The study proposes a more specific definition of the SE, namely the conditional SE (CSE), and a more flexible definition of the TE based on joint TE (JTE), namely the conditional JTE (CJTE), for the analysis of information dynamics in multivariate time series. In a protocol evoking a gradual sympathetic activation and vagal withdrawal proportional to the magnitude of the orthostatic stimulus, such as the graded head-up tilt, we extracted the beat-to-beat spontaneous variability of heart period (HP), systolic arterial pressure (SAP) and respiratory activity (R) in 19 healthy subjects and we computed SE of HP, CSE of HP given SAP and R, JTE from SAP and R to HP, CJTE from SAP and R to HP given SAP and CJTE from SAP and R to HP given R. CSE of HP given SAP and R was significantly smaller than SE of HP and increased progressively with the amplitude of the stimulus, thus suggesting that dynamics internal to HP and unrelated to SAP and R, possibly linked to sympathetic activation evoked by head-up tilt, might play a role during the orthostatic challenge. While JTE from SAP and R to HP was independent of tilt table angle, CJTE from SAP and R to HP given R and from SAP and R to HP given SAP showed opposite trends with tilt table inclination, thus suggesting that the importance of the cardiac baroreflex increases and the relevance of the cardiopulmonary pathway decreases during head-up tilt. The study demonstrates the high specificity of CSE and the high flexibility of CJTE over real data and proves that they are particularly helpful in disentangling physiological mechanisms and in assessing their different contributions to the overall cardiovascular regulation. (AU) | |
| FAPESP's process: | 10/52070-4 - New approaches for evaluation of cardiovascular oscillations changes with aging |
| Grantee: | Aparecida Maria Catai |
| Support Opportunities: | Regular Research Grants |