Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Intrahippocampal injection of TsTX-I increases the levels of INF-gamma in the cerebral tissue but not the levels of glutamate

Full text
Author(s):
Rodriguez, Renan Volner [1, 2] ; Coronado Dorce, Valquiria Abrao [1] ; de Freitas, Lucas Alves [1] ; Coronado Dorce, Ana Leticia [1] ; Lebrun, Ivo [3] ; Martins Sobral, Ana Claudia [1] ; Vieira Portaro, Fernanda Calheta [4] ; Kuniyoshi, Alexandre Kazuo [4] ; Carvalho, Daniela Cajado [4] ; Abrandao Nencioni, Ana Leonor [1]
Total Authors: 10
Affiliation:
[1] Butantan Inst, Pharmacol Lab, BR-05503900 Sao Paulo, SP - Brazil
[2] Butantan Inst, Postgrad Program Toxinol, BR-05503900 Sao Paulo, SP - Brazil
[3] Butantan Inst, Biochem & Biophys Lab, BR-05503900 Sao Paulo, SP - Brazil
[4] Butantan Inst, Lab Immunochem, BR-05503900 Sao Paulo, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Toxicon; v. 103, p. 155-159, SEP 1 2015.
Web of Science Citations: 3
Abstract

TsTX-I, isolated from Tityus serrulatus scorpion venom, causes epileptic-like discharges when injected into the central nervous system. The involvement of excitatory amino acids and cytokines in this activity was investigated. Our results have demonstrated that TsTX-I increases the release of IFN-gamma but does not alter the intracerebral concentration of the excitatory amino acids in rats. Thus, this cytokine seems to be more important in the convulsive process than glutamate. (C) 2015 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 09/54710-3 - Effects of toxins isolated from Tityus serrulatus scorpion venom on hippocampal levels of biogenic amines, excitatory amino acids, and cytokines in rats
Grantee:Ana Leonor Abrahao Nencioni Soares
Support Opportunities: Regular Research Grants