Effect of Zinc Supplementation on Serological Response to Vaccination Against Streptococcus Pneumoniae in Patients Undergoing Chemotherapy for Colorectal Cancer

Author(s)

Moreno Braga, Camila Bitu ^[1] ; Ferreira de Miranda Santos, Isabel Kinney ^[2] ; Palmeira, Patricia ^[3] ; Peria, Fernanda Maris ^[4] ; de Figueiredo Ribeiro, Sofia Miranda ^[5] ; Martinez, Edson Zangiacomi ^[6] ; Ribeiro da Rocha, Jose Joaquim ^[7] ; de Carvalho da Cunha, Selma Freire ^[8]

Affiliation

^[1] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Internal Med, Div Nutrol, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Immunol & Biochem, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Sch Med, Dept Pediat, Lab Med Invest, Sao Paulo, SP - Brazil

^[4] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Internal Med, Div Clin Oncol, Sao Paulo, SP - Brazil

^[5] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Internal Med, Div Nutrol, Sao Paulo, SP - Brazil

^[6] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Social Med, Sao Paulo, SP - Brazil

^[7] Univ Sao Paulo, Sch Med Ribeirao Preto, Sch Med, Dept Surg, Sao Paulo, SP - Brazil

^[8] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Internal Med, BR-14049900 Ribeirao Preto, SP - Brazil

• Document type: Journal article
• Source: NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL; v. 67, n. 6, p. 926-932, AUG 18 2015.
• Web of Science Citations: 3

Abstract

The aim of the study was to evaluate the effect of zinc supplementation on the antibody titer and the 23-valent pneumococcal seroconversion after vaccination in patients undergoing chemotherapy for colorectal cancer. The study included 25 patients undergoing postsurgery chemotherapy for colorectal adenocarcinoma (chemo group). Subjects were assessed in the perioperative period (prevaccination), before chemotherapy (4thwk) and after 3 cycles of chemotherapy (16thwk). Thirty-two healthy volunteers (control group) were included in the study. Participants received the 23-valent pneumococcal conjugate vaccine, and capsules containing zinc (Zn) sulfate (70mg daily) or identical placebo capsules (containing wheat starch with no added Zn) for 16wk and were randomly allocated on one of the following groups: chemo-Zn (n = 10), chemo-placebo (n = 15), control-Zn (n = 21), and control-placebo (n = 11). The antipneumococcal antibody titer against 6 polysaccharides was analyzed by ELISA and compared using linear mixed models. The seroconversion rate was compared using Fisher's exact test. An immune response to the vaccination against pneumococcus was observed in all participants. In the 16thwk, the polysaccharide 6 concentration was lower in the chemo-Zn group {[}2.96 (1.74-5.03) g/mL] compared with the Chemo-Placebo group {[}10.75 (5.37-21.54) g/mL] and the seroconversion rate was lower in the chemo-placebo (36%) compared with the control-placebo (85%) (P = 0.027). Zinc supplementation did not change the antibody titer after vaccination. However, the lower seroconversion rate observed in the chemo-placebo suggests an influence of zinc in the vaccinal protection. (AU)

• FAPESP's process: 10/08787-1 - Modulation of immune response by oral zinc supplementation in adjuvant chemotherapy for colon cancer: a study of global gene expression and function of humoral immunity and neutrophils
• Grantee: Selma Freire de Carvalho
• Support Opportunities: Regular Research Grants