| Full text | |
| Author(s): |
Peruquetti, Rita Luiza
[1]
Total Authors: 1
|
| Affiliation: | [1] Univ Sagrado Coracao, Hlth Sci Ctr, BR-17011160 Sao Paulo - Brazil
Total Affiliations: 1
|
| Document type: | Review article |
| Source: | Animal Reproduction Science; v. 159, p. 8-16, AUG 2015. |
| Web of Science Citations: | 3 |
| Abstract | |
Several genetic and epigenetic events that take place in the nucleus (i.e. meiotic recombination, meiotic silencing, chromatin reorganization and histone replacement) are crucial for the spermatogenesis process, as well as, is the assembling of cytoplasmic bodies (or chromatoid bodies). In this minireview, we give special attention to the most recent research approaches involved in the molecular structure and physiology of the chromatoid body (CB). Though it was described several decades ago, the CB is still a very intriguing cytoplasmic structure of male germ cells. It plays roles in the most important steps of the spermatozoon formation, such as mRNA regulation, smallRNA-mediated gene control, and cell communication among round spermatids. Studies that have been done on the CB largely focus on two main topics: (1) CB proteome, in this minireview focused on `Evidences linking the nucleolar cycle and the CB assembling; and Circadian proteins found in the CB'; and (2) CB transcriptome, in this minireview focused on `miRNAs and piRNAs pathways; and X but not Y chromosome transcripts enriching the CB'. Herein, we described the most relevant results produced in each of these subjects in order to clarify the main physiological role played by this intriguing cytoplasmic structure in the germ cells of male mammals, which though long since described, still fascinates researchers in the field. (C) 2015 Elsevier B.V. All rights reserved. (AU) | |
| FAPESP's process: | 13/14102-0 - Expression of nucleolar protein fibrillarin in mammal's seminiferous tubules at different developmental stages and its physical interaction with chromatoid bodies molecular components |
| Grantee: | Larissa Fiamengui de Pauli |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| FAPESP's process: | 13/26797-2 - Prepubertal exposure to low doses of associated methylmercury and aroclor: evaluation of reproductive parameters of pubescent and adult male rats |
| Grantee: | Mariana Simões Garcia |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| FAPESP's process: | 12/22009-7 - Distribution of nucleolar protein fibrillarin in the seminiferous epithelium of mammals and its role in the chromatoid bodies physiology |
| Grantee: | Rita Luiza Peruquetti |
| Support Opportunities: | Regular Research Grants |