Norepinephrine responses in rat renal and femoral veins are reinforced by vasoconstrictor prostanoids

Author(s)

Rossignoli, Patricia de Souza ^[1] ; Yamamoto, Fernanda Zocatelli ^[2] ; Marques Pereira, Oduvaldo Camara ^[3] ; Chies, Agnaldo Bruno ^[2]

Affiliation

^[1] Sao Paulo State Univ, UNESP, Dept Physiotherapy & Occupat Therapy, Sao Paulo, SP - Brazil

^[2] Fac Med Marilia, Pharmacol Lab, BR-17519030 Sao Paulo, SP - Brazil

^[3] Sao Paulo State Univ, UNESP, Inst Biosci, Dept Pharmacol, Sao Paulo, SP - Brazil

• Document type: Journal article
• Source: VASCULAR PHARMACOLOGY; v. 72, p. 93-100, SEP 2015.
• Web of Science Citations: 1

Abstract

Norepinephrine (NE) responses are larger in renal and femoral veins compared to phenylephrine (PE). These differences may be due to the subtypes of adrenoceptor involved in these responses or to the involvement of local modulatory mechanisms. Therefore, the present study investigated in organ bath the adrenoceptor subtypes involved in the NE and PE responses in both renal and femoral veins as well as the influence of local mechanisms related to NO and to prostanoids upon these responses. The obtained data showed that the NE responses in these veins were not significantly modified by the selective inhibition of beta 1 or beta 2-adrenoceptors as well as AT(1) or AT(2) receptors. However, yohimbine reduced the NE R-max in renal veins and, in parallel, right shifted the NE concentration response curves in femoral veins. In both veins, prazosin reduced the NE R-max and the clonidine induced a measurable contraction. The endothelium removal attenuated the NE responses in femoral veins, thereby abolishing the differences of NE and PE responses. Furthermore, the NE responses in renal and femoral veins were attenuated by indomethacin, which suppressed the statistical difference in relation to the PE response. In conclusion, a synergism between alpha(1)- and alpha(2)-adrenoceptors is essential to assure full NE contractile responses in both renal and femoral veins. Thus, by acting simultaneously in these adrenoceptors, NE induces more pronounced contractile responses, in comparison to PE, not only in renal but also in femoral veins. Moreover, this pronounced NE response in both renal and femoral veins appears to involve endothelium-derived vasoconstrictor prostanoids. (C) 2015 Elsevier Inc. All rights reserved. (AU)

• FAPESP's process: 11/02097-6 - Participation of beta-adrenoceptors in the contraction of rat renal and femoral veins induced by sympathomimetic agonists
• Grantee: Agnaldo Bruno Chies
• Support Opportunities: Regular Research Grants