Antischistosomal and Cytotoxic Effects of the Essential Oil of Tetradenia riparia (Lamiaceae)

Author(s)

de Melo, Nathalya I. ^[1] ; Mantovani, Andre L. L. ^[1] ; de Oliveira, Pollyanna F. ^[1] ; Groppo, Milton ^[2] ; da Silva Filho, Ademar A. ^[3] ; Rodrigues, Vanderlei ^[4] ; Cunha, Wilson R. ^[1] ; Tavares, Denise C. ^[1] ; Magalhaes, Lizandra G. ^[1] ; Crotti, Antonio E. M. ^{[2, 1]}

Affiliation

^[1] Univ Franca, Nucleo Pesquisas Ciencias Exatas, BR-14404600 Franca, SP - Brazil

^[2] Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, BR-14040901 Ribeirao Preto, SP - Brazil

^[3] Univ Fed Juiz de Fora, Fac Farm & Bioquim, BR-36036900 Juiz De Fora, MG - Brazil

^[4] Univ Sao Paulo, Fac Med Ribeirao Preto, BR-14040900 Ribeirao Preto, SP - Brazil

• Document type: Journal article
• Source: NATURAL PRODUCT COMMUNICATIONS; v. 10, n. 9, p. 1627-1630, SEP 2015.
• Web of Science Citations: 4

Abstract

This paper reports on the antischistosomal and cytotoxic effects of the essential oil obtained from Tetradenia riparia leaves (TR-EO). At concentrations of 50 and 100 mu g/mL, TR-EO killed all the worms after 120 and 24 h of incubation, respectively. At a concentration equal to or higher than 50 mu g/mL, this oil also separated the coupled pairs and decreased the adult worm motor activity after incubation periods higher than 72 h. In addition, at 120 h of incubation, TR-EO slightly decreased the number of eggs produced by Schistosoma mansoni adult worms and significantly reduced the percentage of developed eggs, in a dose-dependent manner. XTT-colorimetric assays showed that the tested TR-EO concentrations were not considerably cytotoxic to V79 cells (IC50 = 253.5 mu g/mL). The effects of TR-EO on egg development were noteworthy; therefore, this essential oil deserves further investigation to identify the chemical constituents that elicit activity against S. mansoni. (AU)

• FAPESP's process: 11/05732-4 - Study of cytotoxic and genotoxic potential of Solanum lycocarpum and their majoritary compounds and their influence on genotoxicity induced by different mutagens
• Grantee: Denise Crispim Tavares Barbosa
• Support Opportunities: Regular Research Grants
• FAPESP's process: 09/15207-4 - Evaluation of the effect of lignans and neolignans on Schistosoma mansoni: a proteomic study
• Grantee: Lizandra Guidi Magalhães
• Support Opportunities: Scholarships in Brazil - Post-Doctoral