| Full text | |
| Author(s): Show less - |
Gadelha, Ary
[1, 2]
;
Yonamine, Camila M.
[3, 1]
;
Nering, Marcela
[3]
;
Rizzo, Lucas Bortolotto
[1]
;
Noto, Cristiano
[1, 2]
;
Cogo-Moreira, Hugo
[1]
;
Teixeira, Antonio Lucio
[4]
;
Bressan, Rodrigo
[1, 2]
;
Maes, Michael
[5, 6]
;
Brietzke, Elisa
[1]
;
Hayashi, Mirian A. F.
[3, 1]
Total Authors: 11
|
| Affiliation: | [1] Univ Fed Sao Paulo, Interdisciplinary Lab Clin Neurosci LiNC, BR-04039032 Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Dept Psychiat, Schizophrenia Program ProEsq, BR-04039032 Sao Paulo - Brazil
[3] Univ Fed Sao Paulo, Dept Pharmacol, BR-04039032 Sao Paulo - Brazil
[4] Univ Fed Minas Gerais, Translat Psychoneuroimmunol Grp, Belo Horizonte, MG - Brazil
[5] Chulalongkorn Univ, Fac Med, Dept Psychiat, Bangkok 10330 - Thailand
[6] Deakin Univ, IMPACT Res Ctr, Geelong, Vic 3217 - Australia
Total Affiliations: 6
|
| Document type: | Journal article |
| Source: | PSYCHIATRY RESEARCH; v. 229, n. 3, p. 702-707, OCT 30 2015. |
| Web of Science Citations: | 9 |
| Abstract | |
Previous studies of our group showed increased plasmatic Angiotensin-I Converting Enzyme (ACE) activity in schizophrenia (SCZ) patients compared to healthy controls, which was also associated to poor cognitive functioning. The ACE main product angiotensin II (Ang-II) has pro-inflammatory properties. Activated immune-inflammatory responses in SCZ and their association with disease progression and cognitive impairments are also well-described. Therefore, we examined here the association of plasma ACE activity and inflammatory mediators in 33 SCZ patients and 92 healthy controls. Non-parametric correlations were used to investigate the association of the enzyme activity and the peripheral levels of immune inflammatory markers as interleukins, tumor necrosis factor (TNF-alpha), and interferon (IFN-gamma). Although no significant correlations could be observed for ACE activity and measured cytokines levels in healthy controls, a significant positive correlation for ACE enzymatic activity and IL-17a levels was observed in SCZ patients. Correcting for gender did not change these results. Moreover, a significant association for ACE activity and IFN-gamma levels was also observed. To our knowledge, this is the first study to show a significant association between higher ACE activity and the levels of cytokines, namely IL-17a and IFN-gamma, in patients with SCZ. (C) 2015 Elsevier Ireland Ltd. All rights reserved. (AU) | |
| FAPESP's process: | 09/17726-9 - Identification and characterization of Ndel1 ligants, promoter regulation and characterization of the enzymatic activity |
| Grantee: | Mirian Akemi Furuie Hayashi |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 13/13392-4 - Evaluation of the use of analogs of crotamine for diagnosis or therapy |
| Grantee: | Mirian Akemi Furuie Hayashi |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 11/50740-5 - Prevention in schizophrenia and bipolar disorder from neuroscience to the community: a multiphase, multimodal and translational platform for research and intervention |
| Grantee: | Rodrigo Affonseca Bressan |
| Support Opportunities: | Research Projects - Thematic Grants |