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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Angiotensin converting enzyme activity is positively associated with IL-17a levels in patients with schizophrenia

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Gadelha, Ary [1, 2] ; Yonamine, Camila M. [3, 1] ; Nering, Marcela [3] ; Rizzo, Lucas Bortolotto [1] ; Noto, Cristiano [1, 2] ; Cogo-Moreira, Hugo [1] ; Teixeira, Antonio Lucio [4] ; Bressan, Rodrigo [1, 2] ; Maes, Michael [5, 6] ; Brietzke, Elisa [1] ; Hayashi, Mirian A. F. [3, 1]
Total Authors: 11
[1] Univ Fed Sao Paulo, Interdisciplinary Lab Clin Neurosci LiNC, BR-04039032 Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Dept Psychiat, Schizophrenia Program ProEsq, BR-04039032 Sao Paulo - Brazil
[3] Univ Fed Sao Paulo, Dept Pharmacol, BR-04039032 Sao Paulo - Brazil
[4] Univ Fed Minas Gerais, Translat Psychoneuroimmunol Grp, Belo Horizonte, MG - Brazil
[5] Chulalongkorn Univ, Fac Med, Dept Psychiat, Bangkok 10330 - Thailand
[6] Deakin Univ, IMPACT Res Ctr, Geelong, Vic 3217 - Australia
Total Affiliations: 6
Document type: Journal article
Source: PSYCHIATRY RESEARCH; v. 229, n. 3, p. 702-707, OCT 30 2015.
Web of Science Citations: 9

Previous studies of our group showed increased plasmatic Angiotensin-I Converting Enzyme (ACE) activity in schizophrenia (SCZ) patients compared to healthy controls, which was also associated to poor cognitive functioning. The ACE main product angiotensin II (Ang-II) has pro-inflammatory properties. Activated immune-inflammatory responses in SCZ and their association with disease progression and cognitive impairments are also well-described. Therefore, we examined here the association of plasma ACE activity and inflammatory mediators in 33 SCZ patients and 92 healthy controls. Non-parametric correlations were used to investigate the association of the enzyme activity and the peripheral levels of immune inflammatory markers as interleukins, tumor necrosis factor (TNF-alpha), and interferon (IFN-gamma). Although no significant correlations could be observed for ACE activity and measured cytokines levels in healthy controls, a significant positive correlation for ACE enzymatic activity and IL-17a levels was observed in SCZ patients. Correcting for gender did not change these results. Moreover, a significant association for ACE activity and IFN-gamma levels was also observed. To our knowledge, this is the first study to show a significant association between higher ACE activity and the levels of cytokines, namely IL-17a and IFN-gamma, in patients with SCZ. (C) 2015 Elsevier Ireland Ltd. All rights reserved. (AU)

FAPESP's process: 09/17726-9 - Identification and characterization of Ndel1 ligants, promoter regulation and characterization of the enzymatic activity
Grantee:Mirian Akemi Furuie Hayashi
Support Opportunities: Regular Research Grants
FAPESP's process: 13/13392-4 - Evaluation of the use of analogs of crotamine for diagnosis or therapy
Grantee:Mirian Akemi Furuie Hayashi
Support Opportunities: Regular Research Grants
FAPESP's process: 11/50740-5 - Prevention in schizophrenia and bipolar disorder from neuroscience to the community: a multiphase, multimodal and translational platform for research and intervention
Grantee:Rodrigo Affonseca Bressan
Support Opportunities: Research Projects - Thematic Grants