Repetitive Transcranial Magnetic Stimulation (rTMS) for the cognitive rehabilitation of traumatic brain injury (TBI) victims: study protocol for a randomized controlled trial

Author(s):Show less -

Neville, Iuri Santana ^{[1, 2, 3]} ; Hayashi, Cintya Yukie ^{[2, 4]} ; El Hajj, Simone Alves ^[5] ; Costa Zaninotto, Ana Luiza ^{[5, 2]} ; Sabino, Juliana Perez ^[5] ; Sousa, Jr., Leonardo Moura ^{[1, 2, 3]} ; Nagumo, Marcia Mitie ^[2] ; Brunoni, Andre Russowsky ^{[2, 3]} ; Silva Shieh, Barbara Dal Forno ^[5] ; Oliveira Amorim, Robson Luis ^{[1, 2, 3]} ; Teixeira, Manoel Jacobsen ^{[1, 2, 3]} ; Paiva, Wellingson Silva ^{[1, 2, 3]}

Affiliation

^[1] Univ Sao Paulo, Hosp Clin, Div Neurosurg, BR-05403010 Sao Paulo, SP - Brazil

^[2] Univ Sao Paulo, Serv Interdisciplinary Neuromodulat, BR-05403010 Sao Paulo, SP - Brazil

^[3] Univ Sao Paulo, Hosp Clin, Inst Psychiat, BR-05403010 Sao Paulo, SP - Brazil

^[4] Univ Sao Paulo, Sch Nursing, BR-05403010 Sao Paulo, SP - Brazil

^[5] Univ Sao Paulo, Hosp Clin, Div Neuropsychol, BR-05403010 Sao Paulo, SP - Brazil

• Document type: Journal article
• Source: Trials; v. 16, OCT 5 2015.
• Web of Science Citations: 6

Abstract

Background: Repetitive Transcranial Magnetic Stimulation (rTMS) has been proposed as a new tool in neurological rehabilitation of victims of traumatic brain injury (TBI). However, its usefulness to treat this condition has never been tested rigorously. The primary goal is to conduct a study protocol to determine whether rTMS used to cognitive rehabilitation of victims of TBI with diffuse axonal injury (DAI) is a safe instrument and if it enhances cognitive function recovery. Methods: Double-blind randomized controlled trial of patients with diffuse axonal injury. Thirty-six patients will be randomized to either an active coil group or sham group in a 1: 1 ratio. rTMS protocol: 10 sessions of high-frequency rTMS (10 Hz) over the left dorsolateral prefrontal cortex (DLPFC). Cortical Excitability measures will be obtained. Neuropsychological evaluations will be performed 1 week before, 1 week and 3 months after rTMS. There are 2 study hypotheses: (1) rTMS over the left DLPFC in patients with DAI will improve cognitive function and (2) whether rTMS is safe in TBI patients. Discussion: This study evaluates the immediate and delayed effects of rTMS over the DLPFC on the cognitive domain of patients with DAI following TBI. rTMS has shown good results in treating major depression and may be promising for patients with TBI. As such, the results of this study can greatly modify the cognitive rehabilitation strategies. (AU)

• FAPESP's process: 12/20911-5 - Escitalopram and transcranial direct current stimulation in major depressive disorder: a double blind, placebo-controlled, randomized, non-inferiority trial
• Grantee: Andre Russowsky Brunoni
• Support Opportunities: Research Grants - Young Investigators Grants