Evangelista, Fabiana S.
Muller, Cynthia R.
Stefano, Jose T.
Torres, Mariana M.
Muntanelli, Bruna R.
Alvares-da-Silva, Mario R.
Pereira, Isabel V.
Carrilho, Flair J.
Oliveira, Claudia P.
Total Authors: 11
 Univ Sao Paulo, Sch Arts Sci & Humanities, BR-03828000 Sao Paulo, SP - Brazil
 Univ Sao Paulo, Fac Med, Expt Pathophysiol Dept, BR-03828000 Sao Paulo, SP - Brazil
 Univ Sao Paulo, Fac Med, Gastroenterol Dept LIM 07, BR-03828000 Sao Paulo, SP - Brazil
 Luterana Univ Brazil ULBRA, Mol & Cellular Biol Appl Hlth Dept, Canoas, RS - Brazil
 Univ Fed Rio Grande do Sul, Clin Hosp Porto Alegre, Div Gastroenterol, Porto Alegre, RS - Brazil
Total Affiliations: 5
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE;
Web of Science Citations:
This study sought to determine the role of physical training (PT) on body weight (BW), energy balance, histological markers of nonalcoholic fatty liver disease (NAFLD) and metabolic gene expression in the liver of ob/ob mice. Adult male ob/ob mice were assigned into groups sedentary (S; n = 8) and trained (T; n = 9). PT consisted in running sessions of 60 min at 60% of maximal speed conducted five days per week for eight weeks. BW of S group was higher from the 4th to 8th week of PT compared to their own BW at the beginning of the experiment. PT decreased daily food intake and increased resting oxygen consumption and energy expenditure in T group. No difference was observed in respiratory exchange ratio, but the rates of carbohydrate and lipids oxidation, and maximal running capacity were greater in T than S group. Both groups showed liver steatosis but not inflammation. PT increased CPT1a and SREBP1c mRNA expression in T group, but did not change MTP, PPAR-alpha, PPAR-gamma, and NFKB mRNA expression. In conclusion, PT prevented body weight gain in ob/ob mice by inducing negative energy balance and increased physical exercise tolerance. However, PT did not change inflammatory gene expression and failed to prevent liver steatosis possible due to an upregulation in the expression of SREBP1c transcription factor. These findings reveal that PT has positive effect on body weight control but not in the liver steatosis in a leptin deficiency condition. (AU)