| Full text | |
| Author(s): Show less - |
Batistuzzo, Marcelo Camargo
[1]
;
Balardin, Joana Bisol
[1]
;
Morais Martin, Maria da Graca
[2]
;
Hoexter, Marcelo Queiroz
[3]
;
Bernardes, Elisa Teixeira
[3]
;
Borcato, Sonia
[3]
;
de Marco e Souza, Marina
[3]
;
Querido, Cicero Nardini
[3]
;
Morais, Rosa Magaly
[3]
;
de Alvarenga, Pedro Gomes
[3]
;
Lopes, Antonio Carlos
[3]
;
Shavitt, Roseli Gedanke
[3]
;
Savage, Cary R.
;
Amaro, Jr., Edson
[2]
;
Miguel, Euripedes C.
[3]
;
Polanczyk, Guilherme V.
[3]
;
Miotto, Eliane C.
[1]
Total Authors: 17
|
| Affiliation: | [1] Univ Sao Paulo, Med Sch FMUSP, BR-01060970 Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Fac Med, Dept Radiol, BR-01060970 Sao Paulo, SP - Brazil
[3] FMUSP, Natl Inst Dev Psychiat Children & Adolescents, Obsess Compuls Spectrum Disorders Program PROTOC, Sao Paulo - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY; v. 54, n. 10, p. 849-858, OCT 2015. |
| Web of Science Citations: | 2 |
| Abstract | |
Objective: Patients with obsessive-compulsive disorder (OCD) often present with deficits in episodic memory, and there is evidence that these difficulties may be secondary to executive dysfunction, that is, impaired selection and/or application of memory-encoding strategies (mediation hypothesis). Semantic clustering is an effective strategy to enhance encoding of verbal episodic memory (VEM) when word lists are semantically related. Self-initiated mobilization of this strategy has been associated with increased activity in the prefrontal cortex, particularly the orbitofrontal cortex, a key region in the pathophysiology of OCD. We therefore studied children and adolescents with OCD during uncued semantic, clustering strategy application in a VEM functional magnetic resonance imaging (fMRI)-encoding paradigm. Method: A total of 25 pediatric patients with OCD (aged 8.1-17.5 years) and 25 healthy controls (HC, aged 8.1-16.9) matched for age, gender, handedness, and IQ were evaluated using a block design VEM paradigm that manipulated semantically related and unrelated words. Results: The semantic clustering strategy score (SCS) predicted VEM performance in HC (p <.001, R-2 = 0.635), but not in patients (p =.099). Children with OCD also presented hypoactivation in the dorsomedial prefrontal cortex (cluster-corrected p <.001). Within-group analysis revealed a negative correlation between Yale-Brown Obsessive Compulsive Scale scores and activation of orbitofrontal cortex in the group with OCD. Finally, a positive correlation between age and SCS was found in HC (p = .001, r = 0.635), but not in patients with OCD (p = .936, r = 0.017). Conclusion: Children with OCD presented altered brain activation during the VEM paradigm and absence of expected correlation between SCS and age, and between SCS and total words recalled. These results suggest that different neural mechanisms underlie self-initiated semantic clustering in OCD. (AU) | |
| FAPESP's process: | 09/09949-8 - Episodic verbal memory associated with brain activation in Obsessive-Compulsive Disorder (OCD): functional magnetic resonance imaging analysis |
| Grantee: | Marcelo Camargo Batistuzzo |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |