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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

B-1 cells contribute to susceptibility in experimental infection with Leishmania (Leishmania) chagasi

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Kennerly Marcondes Gonzaga, Wagner Francisco [1] ; Xavier, Vanessa [2] ; Vivanco, Bruno Camolese [1] ; Lopes, Jose Daniel [1, 3] ; Xander, Patricia [2]
Total Authors: 5
[1] Univ Fed Sao Paulo, Dept Microbiol Imunol & Parasitol, BR-04023900 Diadema - Brazil
[2] Univ Fed Sao Paulo, Dept Ciencias Biol, BR-04023900 Diadema - Brazil
[3] Univ Fed Sao Paulo, BR-04023900 Diadema - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Parasitology; v. 142, n. 12, p. 1506-1515, OCT 2015.
Web of Science Citations: 10

The immune response to leishmaniasis is complex, and the result of infection depends on both the genetic composition of the Leishmania species and the immunity of the host. Clinical and experimental evidence suggest that the activation of B cells leads to exacerbation of visceral leishmaniasis. However, the role of B-1 cells (a subtype of B lymphocytes) in the pathogenesis of experimental visceral leishmaniasis has not yet been elucidated. In this study, we investigated the importance of B-1 cells in experimental infection with Leishmania. (L.) chagasi. Our results showed that BALB/XID mice (X-linked immunodeficient mice which are genetically deficient in B-1 cells) infected with L. (L.) chagasi for 45 days had a significant reduction in parasite load in the spleen when compared with control mice. Cytokine analysis showed that the BALB/XID mice had lower amounts of IL-10 in their sera compared with control group. In addition, the transfer of B-1 cells from wild type mice into IL-10KO animals led to an increase in susceptibility to L. (L.) chagasi infection in the IL-10KO mice, suggesting that the IL-10 produced by these cells is important in experimental infection. Our results suggest that B-1 cells may play an important role in susceptibility to L. (L.) chagasi. (AU)

FAPESP's process: 12/11837-6 - Evaluation of B-1 lymphocytes in experimental leishmaniasis
Grantee:Patricia Xander Batista
Support type: Regular Research Grants
FAPESP's process: 10/19569-5 - Study on the role of B-1 lymphocytes during Leishmania (Leishmania) chagasi experimental infection.
Grantee:Vanessa Xavier
Support type: Scholarships in Brazil - Scientific Initiation