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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Development of a novel resin with antimicrobial properties for dental application

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Denise Tornavoi de CASTRO ; Raphael Dias HOLTZ ; Oswaldo Luiz ALVES ; Evandro WATANABE ; Mariana Lima da Costa VALENTE ; Cláudia Helena Lovato da SILVA ; Andréa Cândido dos REIS
Total Authors: 7
Document type: Journal article
Source: Journal of Applied Oral Science; v. 22, n. 5, p. 442-449, Out. 2014.

The adhesion of biofilm on dental prostheses is a prerequisite for the occurrence of oral diseases. Objective: To assess the antimicrobial activity and the mechanical properties of an acrylic resin embedded with nanostructured silver vanadate (β-AgVO3). Material and Methods: The minimum inhibitory concentration (MIC) of β-AgVO3 was studied in relation to the species Staphylococcus aureus ATCC 25923, Streptococcus mutans ATCC 25175, Pseudomonas aeruginosa ATCC 27853, and Candida albicans ATCC 10231. The halo zone of inhibition method was performed in triplicate to determine the inhibitory effect of the modified self-curing acrylic resin Dencor Lay - Clássico®. The surface hardness and compressive strength were examined. The specimens were prepared according to the percentage of β-AgVO3 (0%-control, 0.5%, 1%, 2.5%, 5%, and 10%), with a sample size of 9x2 mm for surface hardness and antimicrobial activity tests, and 8x4 mm for the compression test. The values of the microbiologic analysis were compared and evaluated using the Kruskal-Wallis test (α=0.05); the mechanical analysis used the Shapiro-Wilk's tests, Levene's test, ANOVA (one-way), and Tukey's test (α=0.05). Results: The addition of 10% β-AgVO3 promoted antimicrobial activity against all strains. The antimicrobial effect was observed at a minimum concentration of 1% for P. aeruginosa, 2.5% for S. aureus, 5% for C. albicans, and 10% for S. mutans. Surface hardness and compressive strength increased significantly with the addition of 0.5% β-AgVO3 (p<0.05). Higher rates of the nanomaterial did not alter the mechanical properties of the resin in comparison with the control group (p>0.05). Conclusions: The incorporation of β-AgVO3 has the potential to promote antimicrobial activity in the acrylic resin. At reduced rates, it improves the mechanical properties, and, at higher rates, it does not promote changes in the control. (AU)

FAPESP's process: 12/09124-1 - Characterization and evaluation of mechanical and antimicrobial properties of experimental dental acrylic resins: incorporation with nanostructured silver vanadate
Grantee:Andréa Cândido dos Reis
Support type: Regular Research Grants
FAPESP's process: 12/09347-0 - Influence of the incorporation of nanostructured silver vanadato in antimicrobial activity, morphology and mechanical properties of acrylic resins experimental.
Grantee:Denise Tornavoi de Castro
Support type: Scholarships in Brazil - Master