Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effects of estrogen deficiency combined with chronic alcohol consumption on rat mandibular condyle

Full text
Author(s):
Miriane Carneiro Machado Salgado [1] ; Adriana Mathias Pereira da Silva Marchini [2] ; Tábata de Mello Tera [3] ; Rosilene Fernandes da Rocha [4] ; Leonardo Marchini [5]
Total Authors: 5
Affiliation:
[1] Universidade Estadual Paulista. Instituto de Ciência e Tecnologia - Brasil
[2] Universidade Estadual Paulista. Instituto de Ciência e Tecnologia - Brasil
[3] Universidade Estadual Paulista. Instituto de Ciência e Tecnologia - Brasil
[4] Universidade Estadual Paulista. Instituto de Ciência e Tecnologia - Brasil
[5] University of Iowa. College of Dentistry. Department of Preventive and Community Dentistry
Total Affiliations: 5
Document type: Journal article
Source: Braz. J. Oral Sci.; v. 14, n. 1, p. 16-22, 2015-03-00.
Abstract

Estrogen deficiency and chronic alcohol consumption may have a synergistic and deleterious effect on bone tissue. AIM: To investigate the effects of estrogen deficiency associated with chronic alcohol consumption on the mandibular condyle in rats. METHODS: Fifty-four female rats were first divided equally into two groups: ovariectomized Ovx and simulated ovariectomy Sham. One month after the surgeries, these groups were equally sub-divided according to their dietary treatment: G1: Sham/ad-libitum diet; G2: Sham/alcohol; G3: Sham/isocaloric; G4: Ovx/ad-libitum diet; G5: Ovx/alcohol, G6: Ovx/isocaloric. Eight weeks after starting the diets, all animals were anesthetized and sacrificed. The condyles were analyzed histologically, histomorphometrically, and immunohistochemically using the antibodies for bone sialoprotein BSP, osteocalcin OCC and receptor activator of nuclear factor kappa-B ligand RANKL. RESULTS: Histological analysis of the mandibular condyles showed that Ovx and Sham groups presented almost the same characteristics. The histomorphometric analysis showed that there was a statistically significant difference only between Ovx/isocaloric and Ovx/ad-libitum groups p=0.049. No difference was observed in the intensity of BSP, OCC, and RANKL antibody staining between the Ovx/alcohol and the other groups. CONCLUSIONS: It may be concluded that there was no histomorphometric, histological, or RANKL, BSP, and OCC staining differences between the Ovx/alcohol group and other experimental groups. (AU)

FAPESP's process: 11/03447-0 - Effect of estrogen deficiency and alcohol consuption in mandibular condyle in rats
Grantee:Miriane Carneiro Machado Salgado
Support Opportunities: Scholarships in Brazil - Master