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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Argyrophilic grain disease: An underestimated tauopathy

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Author(s):
Roberta Diehl Rodriguez [1] ; Lea Tenenholz Grinberg [2]
Total Authors: 2
Affiliation:
[1] University of São Paulo. Department of Pathology - Brasil
[2] University of São Paulo. Department of Pathology - Brasil
Total Affiliations: 2
Document type: Journal article
Source: Dement. Neuropsychol.; v. 9, n. 1, p. 2-8, 2015-03-00.
Abstract

Argyrophilic grain disease (AGD) is an under-recognized, distinct, highly frequent sporadic tauopathy, with a prevalence reaching 31.3% in centenarians. The most common AGD manifestation is slowly progressive amnestic mild cognitive impairment, accompanied by a high prevalence of neuropsychiatric symptoms. AGD diagnosis can only be achieved postmortem based on the finding of its three main pathologic features: argyrophilic grains, oligodendrocytic coiled bodies and neuronal pretangles. AGD is frequently seen together with Alzheimer's disease-type pathology or in association with other neurodegenerative diseases. Recent studies suggest that AGD may be a defense mechanism against the spread of other neuropathological entities, particularly Alzheimer's disease. This review aims to provide an in-depth overview of the current understanding on AGD. (AU)

FAPESP's process: 12/07526-5 - Argyrophilic grain disease
Grantee:Roberta Diehl Rodriguez
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)