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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Investigation of the cingulate cortex in idiopathic generalized epilepsy

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Author(s):
Braga, Aline M. da S. [1] ; Fujisao, Elaine K. [1] ; Verdade, Roberto C. [1] ; Paschoalato, Romulo P. [1] ; Paschoalato, Ricardo P. [1] ; Yamashita, Seizo [2] ; Betting, Luiz E. [1]
Total Authors: 7
Affiliation:
[1] Sao Paulo State Univ, Dept Neurol Psychol & Psychiat, Botucatu Med Sch, UNESP, Botucatu, SP - Brazil
[2] Sao Paulo State Univ, Dept Trop Dis & Diagnost Imaging, Botucatu Med Sch, UNESP, Botucatu, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Epilepsia; v. 56, n. 11, p. 1803-1811, NOV 2015.
Web of Science Citations: 10
Abstract

ObjectiveStudies using quantitative neuroimaging have shown subtle abnormalities in patients with idiopathic generalized epilepsy (IGE). These findings have several locations, but the midline parasagittal structures are most commonly implicated. The cingulate cortex is related and may be involved. The objective of the current investigation was to perform a comprehensive analysis of the cingulate cortex using multiple quantitative structural neuroimaging techniques. MethodsThirty-two patients (18 women, 30 10 years) and 36 controls (18 women, 32 11 years) were imaged by 3 Tesla magnetic resonance imaging (MRI). A volumetric three-dimensional (3D) sequence was acquired and used for this investigation. Regions-of-interest were selected and voxel-based morphometry (VBM) analyses compared the cingulate cortex of the two groups using Statistical Parametric Mapping (SPM8) and VBM8 software. Cortical analyses of the cingulate gyrus was performed using Freesurfer. Images were submitted to automatic processing using built-in routines and recommendations. Structural parameters were extracted for individual analyses, and comparisons between groups were restricted to the cingulate gyrus. Finally, shape analyses was performed on the anterior rostral, anterior caudal, posterior, and isthmus cingulate using spherical harmonic description (SPHARM). ResultsVBM analyses of cingulate gyrus showed areas of gray matter atrophy, mainly in the anterior cingulate gyrus (972 mm(3)) and the isthmus (168 mm(3)). Individual analyses of the cingulate cortex were similar between patients with IGE and controls. Surface-based comparisons revealed abnormalities located mainly in the posterior cingulate cortex (718.12 mm(2)). Shape analyses demonstrated a predominance of anterior and posterior cingulate abnormalities. SignificanceThis study suggests that patients with IGE have structural abnormalities in the cingulate gyrus mainly localized at the anterior and posterior portions. This finding is subtle and variable among patients. (AU)

FAPESP's process: 11/02961-2 - Investigation of focal epilepsies using quantitative analysis of the video-electroencephalogram and neuroimaging
Grantee:Luiz Eduardo Gomes Garcia Betting
Support Opportunities: Research Grants - Young Investigators Grants
FAPESP's process: 11/16452-2 - Quantitative analysis of generalized discharges of patients with juvenile myoclonic epilepsy using EEG and neuroimaging
Grantee:Aline Marques da Silva Braga
Support Opportunities: Scholarships in Brazil - Master