Exploring the Aldol Reaction in the Synthesis of Bioactive Compounds

Author(s)

Ferreira, Marco A. B. ^[1] ; Dias, Luiz C. ^[2] ; Leonarczyk, Ives A. ^[1] ; Polo, Ellen C. ^[2] ; de Lucca, Jr., Emilio C. ^[2]

Affiliation

^[1] Univ Fed Sao Carlos, Dept Chem, BR-13560 Sao Carlos, SP - Brazil

^[2] Univ Estadual Campinas, Inst Chem, BR-13083970 Campinas, SP - Brazil

• Document type: Journal article
• Source: CURRENT ORGANIC SYNTHESIS; v. 12, n. 5, p. 547-564, 2015.
• Web of Science Citations: 6

Abstract

Carbonyl chemistry, specifically aldol reactions, is one of the most efficient and elegant strategies to build carbon-carbon bonds. In the last 15 years in Brazil, our research group and others have worked on the development and application of stereoselective aldol reactions, with direct application in the asymmetric synthesis of several natural products of biological interest. In this review, we highlight the major Brazilian contributions to this field. (AU)

• FAPESP's process: 11/06722-2 - Total synthesis of nhatrangins A and B
• Grantee: Ellen Christine Polo
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 11/06721-6 - Total synthesis of marinisporolide A
• Grantee: Emílio Carlos de Lucca Júnior
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 13/02311-3 - New approaches in asymmetric synthesis of tetrahydrofuran and tetrahydropyran-derivatives with potential application in the preparation of bioactive molecules
• Grantee: Marco Antonio Barbosa Ferreira
• Support Opportunities: Regular Research Grants
• FAPESP's process: 12/02230-0 - Total synthesis of bioactive compounds: biological tests and design of new analogs
• Grantee: Luiz Carlos Dias
• Support Opportunities: Regular Research Grants