Drug Likeness and Selective Functionalization of Quinoxalines

Author(s)

Ferreira, Samuel R. A. ^[1] ; Franco, Marcia S. F. ^[2] ; Diniz, Evelyn M. L. P. ^{[3, 1]} ; Emery, Flavio da Silva ^[2] ; Clososki, Giuliano Cesar ^[1]

Affiliation

^[1] Univ Sao Paulo, Nucleo Pesquisas Prod Nat & Sintet, BR-14040903 Ribeirao Preto, SP - Brazil

^[2] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Lab Quim Heterocicl & Med, BR-14040903 Ribeirao Preto, SP - Brazil

^[3] Univ Sao Paulo, Dept Quim, Fac Filosofia Ciencias & Letras Ribeirao Preto, BR-14040901 Ribeirao Preto, SP - Brazil

• Document type: Journal article
• Source: CURRENT ORGANIC SYNTHESIS; v. 12, n. 6, p. 714-729, 2015.
• Web of Science Citations: 5

Abstract

In recent years, the pharmacological potential of quinoxalines has received vast interest due to its many applications. This review centers on a critical overview of chemical diversity and physicochemical properties of bioactive quinoxaline libraries. In addition, recent strategies for obtaining structurally diverse quinoxalines using highly selective processes will be discussed. (AU)

• FAPESP's process: 12/14362-9 - New application of organozinc reagents in the synthesis of bioactive substances
• Grantee: Evelyn Mirella Lopes Pina Diniz
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 12/20990-2 - Antiinfective compounds: an evolution in the medicinal chemistry of leishmanicidal tiazoles and the search for new tuberculostic agents
• Grantee: Flavio da Silva Emery
• Support Opportunities: Regular Research Grants
• FAPESP's process: 13/04766-8 - Applycation of new organometallic reagents in the functionalization of substances of synthetic interest
• Grantee: Giuliano Cesar Clososki
• Support Opportunities: Regular Research Grants
• FAPESP's process: 12/08589-0 - Directed functionalization of quinoxalines aiming the synthesis of bioactive compounds
• Grantee: Samuel Remotto Alves Ferreira
• Support Opportunities: Scholarships in Brazil - Doctorate