Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Infusion of D1 Dopamine Receptor Agonist into Medial Frontal Cortex Disrupts Neural Correlates of Interval Timing

Full text
Author(s):
Parker, Krystal L. [1] ; Ruggiero, Rafael N. [1] ; Narayanan, Nandakumar S. [1]
Total Authors: 3
Affiliation:
[1] Univ Iowa, Neurol, Iowa City, IA 52242 - USA
Total Affiliations: 1
Document type: Journal article
Source: FRONTIERS IN BEHAVIORAL NEUROSCIENCE; v. 9, NOV 10 2015.
Web of Science Citations: 18
Abstract

Medial frontal cortical (MFC) dopamine is essential for the organization of behavior in time. Our prior work indicates that blocking D1 dopamine receptors (D1DR) attenuates temporal processing and low frequency oscillations by MFC neuronal networks. Here we investigate the effects of focal infusion of the D1DR agonist SKF82958 into MFC during interval timing. MFC D1DR agonist infusion impaired interval timing performance without changing overall firing rates of MFC neurons. MFG ramping patterns of neuronal activity that reflect temporal processing were attenuated following infusion of MFC D1DR agonist. MFC D1DR agonist infusion also altered MFC field potentials by enhancing delta activity between 1 and 4 Hz and attenuating alpha activity between 8 and 15 Hz. These data support the idea that the influence of D1-dopamine signals on frontal neuronal activity adheres to a U-shaped curve, and that cognition requires optimal levels of dopamine in frontal cortex. (AU)

FAPESP's process: 14/22817-1 - Modulation of prefrontal cortex activity by optogenetic stimulation of ventral tegmental area during fixed interval task: examining how neuronal firing codes timing
Grantee:Rafael Naime Ruggiero
Support Opportunities: Scholarships abroad - Research Internship - Doctorate