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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Lipid Fingerprinting in Mild versus Severe Forms of Gestational Diabetes Mellitus

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Author(s):
Gueuvoghlanian-Silva, Barbara Yasmin [1] ; Cordeiro, Fernanda Bertuccez [2] ; Lobo, Thalita Frutuoso [1] ; Cataldi, Thais Regiani [3] ; Lo Turco, Edson Guimaraes [2] ; Bertolla, Ricardo Pimenta [2] ; Mattar, Rosiane [1] ; Torloni, Maria Regina [1] ; Daher, Silvia [1]
Total Authors: 9
Affiliation:
[1] Univ Fed Sao Paulo, Dept Obstet, Sao Paulo, SP - Brazil
[2] Univ Fed Sao Paulo, Div Urol, Human Reprod Sect, Dept Surg, Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Dept Genet ESALQ USP, Piracicaba, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: PLoS One; v. 10, n. 12 DEC 3 2015.
Web of Science Citations: 3
Abstract

The blood serum lipid profile of women with Gestational Diabetes Mellitus (GDM) is still under study. There are no data on the serum lipid profile of GDM patients with more severe (insulin treated) compared to milder forms (diet treated) GDM. The aim of our study was to analyze the blood serum lipid profile of patients with milder versus more severe forms of GDM and to compare these findings with those of healthy pregnant women. This cross-sectional analytical study included 30 insulin-treated GDM, 30 diet-only GDM and 30 healthy pregnant women. Serum lipid was extracted from the 90 participants and their lipid profiles were analyzed by lipid fingerprinting using liquid-chromatography-mass spectrometry. A total of 143 parent ions were differentially represented in each of the three groups, belonging to the following classes: Glycerophospholipids, Sterol Lipids, Sphingolipids, Prenol Lipids, Fatty Acyls and Glycerolipids. There were significant differences in the lipid profiles of healthy pregnant women compared to GDM patients and also between milder versus more severe forms of GDM. There are marked differences in lipid fingerprinting between healthy pregnant women compared to those with GDM in the third trimester. Moreover, the lipid profile of women with more severe forms of GDM differs considerably from that of women with milder forms of GDM. These findings may be useful to help clarify the pathogenesis of milder and more severe forms of GDM. (AU)

FAPESP's process: 11/14554-2 - Evaluation of the role of galectin-1 in gestational Diabetes mellitus
Grantee:Silvia Daher
Support Opportunities: Regular Research Grants