| Full text | |
| Author(s): |
Mastandrea, Erika Bergamini
[1]
;
Lucchesi, Fatima
[1]
;
Gomes Kitayama, Marcela Mayumi
[1]
;
Figueiredo, Maria Stella
[1]
;
Citero, Vanessa de Albuquerque
[1]
Total Authors: 5
|
| Affiliation: | [1] Univ Fed Sao Paulo Unifesp, Dept Psychiat, EPM, BR-04038030 Sao Paulo, SP - Brazil
Total Affiliations: 1
|
| Document type: | Journal article |
| Source: | São Paulo Medical Journal; v. 133, n. 5, p. 421-427, SEP-OCT 2015. |
| Web of Science Citations: | 4 |
| Abstract | |
CONTEXT AND OBJECTIVE: Health-related quality of life (HRQoL) may be worsened in sickle cell patients due to the presence of psychiatric disorders. The aims of this study were to describe the psychiatric symptoms in Brazilian sickle cell patients and to evaluate the relationship of these symptoms to the genotype of the disease and the subject's HRQoL. DESIGN AND SETTING: Cross-sectional study conducted at the hematology outpatient clinic, Hospital São Paulo. METHODS: Adult patients with sickle cell disease completed the Medical Outcome Study - Short Form 36 and the Patients' Health Questionnaire. Clinical data were gathered from their medical files. Linear regression models were developed to study the dependency of HRQoL domains on the genotype controlling for psychiatric symptoms. RESULTS: In the study period, 110 patients were evaluated. The most frequent psychiatric symptom was depression (30%), followed by anxiety (12.7%) and alcohol abuse (9.1%). Patients with the more severe genotype (SS and Sβthal0) showed lower scores for the "general health" and "role-physical" HRQoL domains, without interference from psychiatric symptoms. In the "role-physical" domain, the more severe genotype operated as a protective factor for HRQoL (β = 0.255; P = 0.007). CONCLUSION: The more severe genotypes worsened HRQoL in two domains of physical health (general health and role-physical), but they did not have any influence on mental health, thus suggesting that physicians should be more attentive to aspects of HRQoL relating to the functionality of sickle cell disease patients, so as to be aware of the limitations that these patient live with. (AU) | |
| FAPESP's process: | 08/00508-6 - Psychiatric Aspects of Sickle Cell Disease in Brazil (PiSCES-BR) |
| Grantee: | Vanessa de Albuquerque Citero |
| Support Opportunities: | Regular Research Grants |