| Full text | |
| Author(s): |
Total Authors: 2
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| Affiliation: | [1] Univ Fed Abc, Av Estados 5001, BR-09210170 Santo Andre, SP - Brazil
Total Affiliations: 1
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| Document type: | Journal article |
| Source: | Journal of the Brazilian Chemical Society; v. 27, n. 1, p. 179-185, JAN 2016. |
| Web of Science Citations: | 2 |
| Abstract | |
The binding interaction of rhenium(I) complexes fac-[Re(CO)3(NN)(py)]+, py = pyridine and NN = 1,10-phenanthroline (phen), 4,7-diphenyl-1,10-phenanthroline (ph2phen) or 4,7-dichloro-1,10-phenanthroline (Cl2phen), and bovine serum albumin (BSA) was investigated at physiological pH using emission intensity variation and circular dichroism (CD) spectroscopy. The photophysical investigations showed that in the presence of BSA, the metal-to-ligand-charge transfer (3MLCT) emission of the rhenium(I) complexes was quenched due to entrapment of the complex within the protein environment. Additionally, high Stern-Volmer (KSV) and binding (Kb) constants were determined from luminescence data, revealing the occurrence of a strong interaction and/or association. The differences in KSV values can be tentatively associated with an electron-withdrawing constant (σ) defined by Hammett equation. The CD results showed that the extent of α-helicity of the BSA decreased upon the addition of rhenium complexes, which provided further support for the interaction of rhenium(I) complexes and the protein. (AU) | |
| FAPESP's process: | 11/23408-0 - Syntheses, characterization and photophysical investigation of rhenium (I) complexes |
| Grantee: | Karina Passalacqua Morelli Frin |
| Support Opportunities: | Regular Research Grants |