Innate immunity in tuberculosis: how the sensing of mycobacteria and tissue damage modulates macrophage death

Author(s)

Amaral, Eduardo P. ^[1] ; Lasunskaia, Elena B. ^[2] ; D'Imperio-Lima, Maria Regina ^[1]

Affiliation

^[1] Univ Sao Paulo, Dept Immunol, Inst Biomed Sci, Sao Paulo - Brazil

^[2] State Univ North Fluminense, Lab Recognit Biol, Ctr Biosci & Biotechnol, Rio De Janeiro - Brazil

• Document type: Review article
• Source: Microbes and Infection; v. 18, n. 1, p. 11-20, JAN 2016.
• Web of Science Citations: 22

Abstract

The success of Mycobacterium tuberculosis as a human pathogen has been attributed to the ability of the bacillus to proliferate inside macrophages and to induce cell death. This review describes how the sensors of the innate immune system modulate the cell death pathways in infected macrophages and, consequently, the pathogenesis of tuberculosis. (C) 2015 The Authors. Published by Elsevier Masson SAS on behalf of Institut Pasteur. (AU)

• FAPESP's process: 10/19246-1 - Role of inflammasome activation in development of the tuberculosis pathogeny induced by hypervirulent clinical isolates
• Grantee: Eduardo Pinheiro Amaral
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 13/07140-2 - Role of inflammasomas in the pathogenesis of tuberculosis caused by hypervirulent clinical isolates of mycobacteria
• Grantee: Maria Regina D'Império Lima
• Support Opportunities: Regular Research Grants