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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effect of collagen sponge and fibrin glue on bone repair

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Author(s):
Santos, Thiago de Santana [1] ; Flores Abuna, Rodrigo Paolo [1] ; Goncalves de Almeida, Adriana Luisa [1] ; Beloti, Marcio Mateus [1] ; Rosa, Adalberto Luiz [1]
Total Authors: 5
Affiliation:
[1] Univ Sao Paulo, Fac Odontol Ribeirao Preto, Lab Cultura Celulas, BR-14040904 Ribeirao Preto, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Journal of Applied Oral Science; v. 23, n. 6, p. 623-628, NOV-DEC 2015.
Web of Science Citations: 10
Abstract

ABSTRACT The ability of hemostatic agents to promote bone repair has been investigated using in vitro and in vivo models but, up to now, the results are inconclusive. Objective In this context, the aim of this study was to compare the potential of bone repair of collagen sponge with fibrin glue in a rat calvarial defect model. Material and Methods Defects of 5 mm in diameter were created in rat calvariae and treated with either collagen sponge or fibrin glue; untreated defects were used as control. At 4 and 8 weeks, histological analysis and micro-CT-based histomorphometry were carried out and data were compared by two-way ANOVA followed by Student-Newman-Keuls test when appropriated (p≤0.05). Results Three-dimensional reconstructions showed increased bone formation in defects treated with either collagen sponge or fibrin glue compared with untreated defects, which was confirmed by the histological analysis. Morphometric parameters indicated the progression of bone formation from 4 to 8 weeks. Additionally, fibrin glue displayed slightly higher bone formation rate when compared with collagen sponge. Conclusion Our results have shown the benefits of using collagen sponge and fibrin glue to promote new bone formation in rat calvarial bone defects, the latter being discreetly more advantageous. (AU)

FAPESP's process: 11/00919-9 - Effect of cell therapy associating mesenchymal stem cells and osteoblasto on bone repair
Grantee:Thiago de Santana Santos
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 11/00617-2 - Effect of cell therapy associating mesenchymal stem cells and osteoblasts on bone repair
Grantee:Adalberto Luiz Rosa
Support Opportunities: Regular Research Grants