| Full text | |
| Author(s): Show less - |
Deus-Silva, Leonardo
[1]
;
Bonilha, Leonardo
[2]
;
Damasceno, Benito P.
[1]
;
Costa, Andre L. F.
[1, 3]
;
Yasuda, Clarissa L.
[1]
;
Costa, Fernando F.
[4]
;
Santos, Allan O.
[5]
;
Etchebehere, Elba C. S. C.
[5]
;
Oquendo-Nogueira, Regis
[5]
;
Fockink, Renata
[5]
;
de Freitas, Claudio Froes
[3]
;
Camargo, Edwaldo E.
[5]
;
Li, Li M.
[1]
;
Cendes, Fernando
[1]
;
Saad, Sara T.
[4]
Total Authors: 15
|
| Affiliation: | [1] Univ Estadual Campinas, Dept Neurol, Campinas, SP - Brazil
[2] Med Univ S Carolina, Dept Neurosci, Div Neurol, Charleston, SC 29425 - USA
[3] City Univ Sao Paulo, Dept Orthodont, Sao Paulo - Brazil
[4] Univ Estadual Campinas, Hematol & Hemotherapy Ctr, Campinas, SP - Brazil
[5] Univ Estadual Campinas, Dept Radiol, Div Nucl Med, Campinas, SP - Brazil
Total Affiliations: 5
|
| Document type: | Journal article |
| Source: | FRONTIERS IN NEUROLOGY; v. 4, 2013. |
| Web of Science Citations: | 3 |
| Abstract | |
Cerebrovascular lesions are frequently observed in patients with sickle-cell disease (SCD) and these structural lesions are preceded by insidious perfusion deficits. Our aim was to investigate the presence of brain perfusion deficits in neurologically asymptomatic SCD patients, especially affecting microvessels. For this study, 42 SCD patients {[}33 sickle-cell anemia (HbSS), 6 sickle hemoglobin C disease (HbSC), and 3 sickle beta-thalassemia disease (HbS beta)] with mean hematocrit of 25.1 (+/- 4.85; 15.6-38.5) underwent brain perfusion single photon emission computerized tomography (SPECT) using the tracer Tc-99m-ECD. Images from SCD patients were compared to images of a healthy control group (29 females and 20 males, mean age 31 +/- 8; range 25-49 years). Images underwent voxel-wise comparison of regional tracer uptake using paired t-test to estimate the probability of each voxel to have an increased or decreased tracer uptake. When compared to controls, SCD patients exhibited significantly reduced tracer uptake in basal ganglia and thalami, the anterior frontal region and the watershed region of the temporo-parietal-occipital transition (p < 0.05). Our study showed that neurologically asymptomatic adult SCD patients exhibit a pattern of reduced 99mTc-ECD tracer uptake demonstrated by SPECT. Early diagnosis of this cerebral vasculopathy has prognostic implications and can be determinant in considering therapeutic alternatives to avoid increasing brain lesion load and progressive disability. (AU) | |