Effects of task complexity on activation of language areas in a semantic decision fMRI protocol

Author(s)

Lopes, Tatila Martins ^[1] ; Yasuda, Clarissa Lin ^[1] ; de Campos, Brunno Machado ^[1] ; Balthazar, Marcio L. F. ^[1] ; Binder, Jeffrey R. ^[2] ; Cendes, Fernando ^[1]

Affiliation

^[1] Univ Estadual Campinas, Dept Neurol, Campinas, SP - Brazil

^[2] Med Coll Wisconsin, Dept Neurol, Milwaukee, WI 53226 - USA

• Document type: Journal article
• Source: Neuropsychologia; v. 81, p. 140-148, JAN 29 2016.
• Web of Science Citations: 8

Abstract

Language tasks used for clinical fMRI studies may be too complex for some patients with cognitive impairments, and ``easier{''} versions are sometimes substituted, though the effects on brain activity of such changes in task complexity are largely unknown. To investigate these differences, we compared two versions of an fMRI language comprehension protocol, with different levels of difficulty, in 24 healthy right-handed adults. The protocol contrasted an auditory word comprehension task (semantic decision) with a nonspeech control task using tone sequences (tone decision). In the ``complex{''} version (CV), the semantic decision task required two complex semantic decisions for each word, and the tone decision task required the participant to count the number of target tones in each sequence. In the ``easy{''} version (EV), the semantic task required only a single easier decision, and the tone task required only detection of the presence or absence of a target tone in each sequence. The protocols were adapted for a Brazilian population. Typical left hemisphere language lateralization was observed in 92% of participants for both CV and EV using the whole-brain lateralization index, and typical language lateralization was also observed for others regions of interest. Task performance was superior on the EV compared to the CV (p=0.014). There were many common areas of activation across the two version; however, the CV produced greater activation in the left superior and middle frontal giri, angular gyrus, and left posterior cingulate gyrus compared to the EV, the majority of which are areas previously identified with language and semantic processing. The EV produced stronger activation only in a small area in the posterior middle temporal gyrus. These results reveal differences between two versions of the protocol and provide evidence that both are useful for language lateralization and worked well for Brazilian population. The complex version produces stronger activation in several nodes of the semantic network and therefore is elected for participants who can perform well these tasks. (C) 2015 Elsevier Ltd. All rights reserved. (AU)

• FAPESP's process: 12/05364-8 - Language assessment in temporal lobe epilepsy: correlations with structural and functional neuroimage.
• Grantee: Tátila Martins Lopes
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 13/07559-3 - BRAINN - The Brazilian Institute of Neuroscience and Neurotechnology
• Grantee: Fernando Cendes
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC