Mathematical biornarkers for the autonomic regulation of cardiovascular system

Author(s)

Campos, Luciana A. ^[1] ; Pereira, Jr., Valter L. ^[1] ; Muralikrishna, Amita ^[2] ; Albarwani, Sulayma ^[3] ; Bras, Susana ^[4] ; Gouveia, Sonia ^[4]

Affiliation

^[1] Camilo Castelo Branco Univ UNICASTELO, Ctr Innovat Technol & Educ, BR-12247004 Sao Jose Dos Campos, SP - Brazil

^[2] Fed Inst Sci & Technol Sao Paulo, Dept Automat & Syst Technol, Sao Jose Dos Campos, SP - Brazil

^[3] Sultan Qaboos Univ, Dept Physiol, Muscat - Oman

^[4] Univ Aveiro, Inst Elect & Telemat Engn Aveiro, P-3800 Aveiro - Portugal

• Document type: Review article
• Source: FRONTIERS IN PHYSIOLOGY; v. 4, 2013.
• Web of Science Citations: 20

Abstract

Heart rate and blood pressure are the most important vital signs in diagnosing disease. Both heart rate and blood pressure are characterized by a high degree of short term variability from moment to moment, medium term over the normal day and night as well as in the very long term over months to years. The study of new mathematical algorithms to evaluate the variability of these cardiovascular parameters has a high potential in the development of new methods for early detection of cardiovascular disease, to establish differential diagnosis with possible therapeutic consequences. The autonomic nervous system is a major player in the general adaptive reaction to stress and disease. The quantitative prediction of the autonomic interactions in multiple control loops pathways of cardiovascular system is directly applicable to clinical situations. Exploration of new multimodal analytical techniques for the variability of cardiovascular system may detect new approaches for deterministic parameter identification. A multimodal analysis of cardiovascular signals can be studied by evaluating their amplitudes, phases, time domain patterns, and sensitivity to imposed stimuli, i.e., drugs blocking the autonomic system. The causal effects, gains, and dynamic relationships may be studied through dynamical fuzzy logic models, such as the discrete-time model and discrete-event model. We expect an increase in accuracy of modeling and a better estimation of the heart rate and blood pressure time series, which could be of benefit for intelligent patient monitoring. We foresee that identifying quantitative mathematical biomarkers for autonomic nervous system will allow individual therapy adjustments to aim at the most favorable sympathetic-parasympathetic balance. (AU)

• FAPESP's process: 13/06698-0 - Mathematical biomarkers for autonomic regulation of cardiovascular system
• Grantee: Luciana Aparecida Campos Baltatu
• Support type: Regular Research Grants
• FAPESP's process: 13/50137-2 - Melatonin modulates barorreflex control via area postrema
• Grantee: Luciana Aparecida Campos Baltatu
• Support type: Regular Research Grants - Publications - Scientific article