| Full text | |
| Author(s): |
Pugliese, Camila
[1]
;
van der Vinne, Roberta T. A.
[1]
;
Campos, Lucia M. A.
[1]
;
Guardieiro, Priscila R.
[2]
;
Saviolli, Cynthia
[2]
;
Bonfa, Eloisa
[3]
;
Pereira, Rosa M. R.
[3]
;
Viana, Vilma S.
[3]
;
Borba, Eduardo F.
[3]
;
Silva, Clovis A.
[1, 3]
Total Authors: 10
|
| Affiliation: | [1] Univ Sao Paulo, Fac Med, Pediat Rheumatol Unit, Av Dr Eneas Carvalho Aguiar, 647 Cerqueira Cesar, BR-05403000 Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Fac Med, Div Dent, Av Dr Eneas Carvalho Aguiar, 647 Cerqueira Cesar, BR-05403000 Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Fac Med, Div Rheumatol, Av Dr Eneas Carvalho Aguiar, 647 Cerqueira Cesar, BR-05403000 Sao Paulo, SP - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | CLINICAL RHEUMATOLOGY; v. 35, n. 1, p. 81-91, JAN 2016. |
| Web of Science Citations: | 5 |
| Abstract | |
The impact of juvenile idiopathic arthritis (JIA) in periodontal diseases is controversial probably due to gender and age heterogeneity. We therefore evaluated a homogeneous female post-pubertal JIA population for these conditions. Thirty-five JIA patients and 35 gender/age comparable healthy controls were evaluated according to demographic data, complete periodontal evaluation, fasting lipoproteins, and anti-lipoprotein lipase antibodies. JIA scores, laboratorial tests, X-rays, and treatment were also assessed. Current age was similar in JIA patients and controls (11.90 +/- 2.0 vs. 12.50 +/- 3.0 years, p=0.289). Complete periodontal assessments revealed that gingival index, dental plaque, gingival bleeding, and clinical dental attachment indices were alike in JIA patients and controls (p>0.05), except for gingival enlargement in former group (p<0.0001). Further analysis of patients with and without gingivitis revealed that cyclosporine use was more often observed in JIA patients with gingivitis (37 vs. 0 %, p=0.01), whereas no differences were evidenced in demographic, JIA scores, inflammatory markers, and lipid profile in both groups. Of note, two parameters of periodontal assessment were correlated with JIA scores {[}gingival index (GI) and Childhood Health Assessment Questionnaire (CHAQ) (r(s)=+0.402, p=0.020)] and plaque index (PI) and visual analog scale (VAS) physician (r(s)=+0.430, p=0.013). In addition, evaluation of dental assessment demonstrated that JIA activity scores had positive correlation with decayed, missing, and filled teeth (DMF-T) and junvenile athritis disease activity score (JADAS) (r(s)=+0.364, p=0.037), VAS physician (r(s)=+0.401, p=0.021) and VAS patient (r(s)=+0.364, p=0.037). We demonstrated, using rigorous criteria, that periodontal and dental condition in JIA is similar to controls. In spite of that, the finding of a correlation with disease parameters provides additional evidence that increased activity and reduced functional ability underlies the deleterious effect of JIA in oral health. (AU) | |
| FAPESP's process: | 08/58238-4 - Autoimmunity in children: investigation of the molecular and cellular bases of early onset of autoimmunity |
| Grantee: | Magda Maria Sales Carneiro-Sampaio |
| Support Opportunities: | Research Projects - Thematic Grants |