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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The total synthesis of calcium atorvastatin

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Author(s):
Dias, Luiz C. [1] ; Vieira, Adriano S. [1] ; Barreiro, Eliezer J. [2]
Total Authors: 3
Affiliation:
[1] Univ Estadual Campinas, UNICAMP, Inst Quim, POB 6154, BR-13084971 Campinas, SP - Brazil
[2] Univ Fed Rio de Janeiro, Lab Avaliacao & Sintese Substancias Bioativas, Box 68024, BR-21944971 Rio De Janeiro, RJ - Brazil
Total Affiliations: 2
Document type: Journal article
Source: ORGANIC & BIOMOLECULAR CHEMISTRY; v. 14, n. 7, p. 2291-2296, 2016.
Web of Science Citations: 12
Abstract

A practical and convergent asymmetric route to calcium atorvastatin (1) is reported. The synthesis of calcium atorvastatin (1) was performed using the remote 1,5-anti asymmetric induction in the boron-mediated aldol reaction of beta-alkoxy methylketone (4) with pyrrolic aldehyde (3) as a key step. Calcium atorvastatin was obtained from aldehyde (3) after 6 steps, with a 41% overall yield. (AU)

FAPESP's process: 12/02230-0 - Total synthesis of bioactive compounds: biological tests and design of new analogs
Grantee:Luiz Carlos Dias
Support Opportunities: Regular Research Grants