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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Short-term effects of catheter-based renal denervation on cardiac sympathetic drive and cardiac baroreflex function in heart failure

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Booth, Lindsea C. [1] ; Schlaich, Markus P. [2] ; Nishi, Erika E. [3, 1] ; Yao, Song T. [1] ; Xu, Jianzhong [2, 4] ; Ramchandra, Rohit [1, 5] ; Lambert, Gavin W. [2] ; May, Clive N. [1]
Total Authors: 8
[1] Florey Inst Neurosci & Mental Hlth, Melbourne, Vic - Australia
[2] Baker IDI Heart & Diabet Inst, Melbourne - Australia
[3] Univ Fed Sao Paulo, Cardiovasc Div, Dept Physiol, Sao Paulo - Brazil
[4] Ruijin Hosp, Shanghai Inst Hypertens, Shanghai - Peoples R China
[5] Univ Auckland, Dept Physiol, Auckland - New Zealand
Total Affiliations: 5
Document type: Journal article
Source: INTERNATIONAL JOURNAL OF CARDIOLOGY; v. 190, p. 220-226, JUL 1 2015.
Web of Science Citations: 16

Objectives: Sympathetic drive, especially to the heart, is elevated in heart failure and is strongly associated with poor outcome. The mechanisms causing the increased sympathetic drive to the heart remain poorly understood. Catheter-based renal denervation (RDN), which reduces blood pressure (BP) and sympathetic drive in hypertensive patients, is a potential treatment in heart failure. The aim of this study was to investigate the short-term effects of catheter-based RDN on BP, heart rate (HR) and cardiac sympathetic nerve activity (CSNA) and on baroreflex function in a conscious, large animal model of heart failure. Methods: Adult Merino ewes were paced into heart failure (ejection fraction <40%) and then instrumented to directly record CSNA. The resting levels and baroreflex control of CSNA and HR were measured before and 24 h after bilateral renal (n = 6) or sham (n = 6) denervation. RDN was performed using the Symplicity Flex Catheter System (R) (Medtronic) using the same algorithm as in patients. Results: Catheter-based RDN significantly reduced resting diastolic BP (P < 0.01) and mean arterial blood pressure (P < 0.05), but did not change resting HR or CSNA compared with sham denervation. Renal denervation reduced the BP at which CSNA was at 50% of maximum (BP50; P < 0.005) compared with sham denervation. Conclusions: In an ovine model of heart failure, catheter-based RDN did not reduce resting CSNA in the short-term. There was, however, a lack of a reflex increase in CSNA in response to the fall in arterial pressure due to a leftward shift in the baroreflex control of CSNA, which may be due to denervation of renal efferent and/or afferent nerves. (C) 2015 Elsevier Ireland Ltd. All rights reserved. (AU)

FAPESP's process: 12/05282-1 - Role of renal nerves in an experimental model of hypertension
Grantee:Erika Emy Nishi
Support type: Scholarships abroad - Research Internship - Doctorate