Quality of Life of Patients with Squamous Cell Carcinoma of the Head and Neck Receiving High-Dose Cisplatin Chemotherapy and Radiotherapy

Author(s)

Visacri, Marilia Berlofa ; Ferrari, Graziele Baldan ; Dias, Pamela ; Pimentel, Rafaela ; de Souza, Cinthia Madeira ; Lourenco Costa, Anna Paula ; Pincinato, Eder de Carvalho ; Passos Lima, Carmen Silvia ; Mazzola, Priscila Gava ; Moriel, Patricia

• Document type: Journal article
• Source: SOUTHERN MEDICAL JOURNAL; v. 108, n. 6, p. 343-349, JUN 2015.
• Web of Science Citations: 5

Abstract

Objectives: The aim of this study was to evaluate the quality of life (QOL) of patients with squamous cell carcinoma of the head and neck before and during treatment with high-dose cisplatin and radiotherapy. Methods: This was an observational and longitudinal prospective study conducted fromJune 2011 toMarch 2013 at the clinical oncology ambulatory unit of a public teaching hospital in Sao Paulo, Brazil. The University of Washington Quality of Life Questionnaire was used to measure the QOL of patients before and after each chemotherapy cycle with high-dose cisplatin (80-100mg/m(2), three cycles) and radiotherapy (2 Gy, 5 days/week for 7 weeks). Data were analyzed using Student t tests, and P < 0.05 was considered statistically significant. Results: Thirty-two patients completed the three cycles of treatment. The study population consisted primarily of white men with a mean age older than 50 years, who had a partner, a low education level, and who were heavy smokers and drinkers, Karnofsky Performance Status of 90% to 100%, pharynx tumors, and stage IV cancer, classified as T4 and N2 stages; the minority of them required interventions such as a feeding tube and tracheostomy. We observed a reduction in QOL after treatment initiation; this reduction was significant after the second chemotherapy cycle and the sixth week of radiotherapy. The abilities to taste, swallow, salivate, and participate in activities and recreation were affected significantly. We also observed a significant improvement in pain and anxiety resulting from the chemoradiation. Conclusions: Healthcare providers need to be aware of the affected domains to provide improved QOL, well-being, and security to cancer patients who are receiving this type of treatment. (AU)

• FAPESP's process: 12/01807-2 - Pharmacogenetics of cisplatin in head and neck squamous cell carcinoma
• Grantee: Carmen Silvia Passos Lima
• Support Opportunities: Regular Research Grants