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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

A case-control study of CYP2E1 (PstI) and CYP1A1 (MspI) polymorphisms in colorectal cancer

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Author(s):
Proenca, M. A. [1, 2] ; Fernandes, G. M. M. [2] ; Russo, A. [2] ; Lelis, R. B. [2] ; Netinho, J. G. [3, 4] ; Cunrath, G. S. [3, 4] ; Silva, A. E. [1] ; Goloni-Bertollo, E. M. [2] ; Pavarino, E. C. [2]
Total Authors: 9
Affiliation:
[1] Univ Estadual Paulista, Dept Biol, Sao Jose Do Rio Preto, SP - Brazil
[2] Fac Med Sao Jose do Rio Preto, Dept Biol Mol, Unidade Pesquisa Genet & Biol Mol, Sao Jose Do Rio Preto, SP - Brazil
[3] Fac Med Sao Jose do Rio Preto, Dept Cirurgia, Sao Jose Do Rio Preto, SP - Brazil
[4] Fac Med Sao Jose do Rio Preto, Serv Ambulatorial Coloproctol, Sao Jose Do Rio Preto, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Genetics and Molecular Research; v. 14, n. 4, p. 17856-17863, 2015.
Web of Science Citations: 1
Abstract

Polymorphisms in genes encoding P450 cytochrome enzymes may increase the risk of sporadic colorectal cancer (SCRC). Here we investigated the association between SCRC and CYP2E1 (PstI) and CYP1A1 (MspI) polymorphisms in a case-control study. Moreover, we sought to determine any possible associations between this disease and the sociodemographic factors. We included 273 individuals (74 patients and 199 controls); the gender, age, tobacco usage, and alcohol consumption of the included subjects, and the clinico-histopathological parameters of the tumors, were analyzed. Molecular analyses were performed using PCR-RFLP. The effect of polymorphisms on SCRC development, and the association between this disease and sociodemographic factors were determined by multiple-logistic regression analyses. The combined genotype was also evaluated. Statistically significant differences between the patients and controls regarding the male gender (odds ratio, OR = 0.19, 95% confidence interval, CI = 0.08-0.46; P <= 0.05) and age >= 44 years (median = 44; OR = 96.84, 95% CI = 21.78-430.49; P <= 0.05) were observed. The evaluated polymorphisms were not associated with SCRC (PstI-CYP2E1: OR = 0.93, 95% CI = 0.30-2.85; P = 0.897; MspI-CYP1A1: OR = 0.75, 95% CI = 0.35-1.61; P = 0.463); the combined genotypes were not associated with the risk of disease. Thus, individuals aged >= 44 years are more sensitive to SCRC, while men are less susceptible. Additionally, polymorphisms in CYP2E1 (PstI) and CYP1A1 (MspI) were not associated with SCRC in the evaluated Brazilian population. (AU)

FAPESP's process: 12/00130-9 - Molecular and epidemiology analysis of the polymorphisms cyp1a1*2c and cyp2e1*6 in patients with colorectal Cancer
Grantee:Roliana Bravo Lelis
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 12/02473-0 - Epidemiological and molecular investigation of genes related to xenobiotic metabolism in patients with sporadic colerrectal cancer
Grantee:Glaucia Maria de Mendonça Fernandes
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 11/23969-1 - Epidemiological and molecular investigation of genes related to xenobiotic metabolism in patients with sporadic colerrectal cancer
Grantee:Eny Maria Goloni Bertollo
Support Opportunities: Regular Research Grants