| Full text | |
| Author(s): |
Carvalho, Jr., Paulo S.
[1]
;
de Melo, Cristiane C.
[1, 2]
;
Ayala, Alejandro P.
[2]
;
da Silva, Cecilia C. P.
[1]
;
Ellena, Javier
[1]
Total Authors: 5
|
| Affiliation: | [1] Univ Sao Paulo, Inst Fis Sao Carlos, CP 369, BR-13560970 Sao Carlos, SP - Brazil
[2] Univ Fed Ceara, Dept Fis, CP 6030, BR-60455970 Fortaleza, Ceara - Brazil
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | Crystal Growth & Design; v. 16, n. 3, p. 1543-1549, MAR 2016. |
| Web of Science Citations: | 13 |
| Abstract | |
For active pharmaceutical ingredients (API) in the solid state, the occurrence of hydration/dehydration phase transitions may have implications upon the efficiency of the pharmaceutical product, once they are often accompanied by Changes of physicochemical properties. Thus, it is important for pharmaceutical research and development to investigate these mechanisms based on the crystal structures of the API. In this work, beyond the structural characterization of a new salt of the antidepressant drug Paroxetine {[}an HBr hemihydrate, (PRX+BC-)center dot 0.5H(2)O], by single crystal X-ray diffraction (SXRD), thermal analysis (DSC/TGA), and hot stage microscopy (HSM), we were able to perform a complete investigation toward the reversible hydration/dehydration solid phase transitions occurring for this salt. In addition, solubility measurements for the anhydrous and hemihydrate solid foams of the new salt are compared with those of its isostructural hydrochloride hemihydrate salt, (PRX+Cl-)center dot 0.5H(2)O, for which hydration/dehydration processes are still not completely understood due to structure instability after dehydration. (AU) | |
| FAPESP's process: | 12/05616-7 - Solid-state characterization of anticonvulsant and antidepressant phamaceutical compounds: Design of new crystal forms. |
| Grantee: | Paulo de Sousa Carvalho Júnior |
| Support Opportunities: | Scholarships in Brazil - Doctorate |