Interplay Between Exosomes, microRNAs and Toll-Like Receptors in Brain Disorders

Author(s)

Paschon, Vera ^{[1, 2]} ; Takada, Silvia Honda ^[1] ; Ikebara, Juliane Midori ^[1] ; Sousa, Erica ^[1] ; Raeisossadati, Reza ^[1] ; Ulrich, Henning ^[3] ; Kihara, Alexandre Hiroaki ^{[1, 2]}

Affiliation

^[1] Univ Fed ABC, Ctr Matemat Computacao & Cognicao, Sao Bernardo Do Campo, SP - Brazil

^[2] Univ Fed ABC, Lab Neurogenet, 112 Bloco Delta R Arcturus 3, BR-09606070 Sao Bernardo Do Campo, SP - Brazil

^[3] Univ Sao Paulo, Inst Quim, Dept Bioquim, Ave Prof Lineu Prestes 748, BR-05508000 Sao Paulo, SP - Brazil

• Document type: Review article
• Source: Molecular Neurobiology; v. 53, n. 3, p. 2016-2028, APR 2016.
• Web of Science Citations: 21

Abstract

Extracellular vesicles (EVs), including exosomes, microvesicles and apoptotic bodies, participate in intercellular communication, and particularly, in paracrine and endocrine signalling. The EVs and their specific contents have been considered hallmarks of different diseases. It has been recently discovered that EVs can co-transport nucleic acids such as DNAs, ribosomal RNAs, circular RNAs (circRNAs), long noncoding RNAs (lnRNAs) and microRNAs (miRNAs). miRNAs are important regulators of gene expression at the post-transcriptional level, although they may also play other roles. Recent evidence supports the hypothesis that miRNAs can activate Toll-like receptors (TLRs) under certain circumstances. TLRs belong to a multigene family of immune system receptors and have been recently described in the nervous system. In the immune system, TLRs are important for the recognition of the invading microorganisms, whereas in the nervous system, they recognise endogenous ligands released by undifferentiated or necrotic/injured cells. In the neuronal disease field, TLRs activity has been associated with amyotrophic lateral sclerosis (ALS), stroke, Alzheimer's and Parkinson's disease. Herein, we reviewed the current knowledge of the relationship between miRNA release by EVs and the inflammation signalling triggered by TLRs in neighbouring cells or during long-distance cell-to-cell communication. We highlight novel aspects of this communication mechanism, offering a valuable insight into such pathways in health and disease. (AU)

• FAPESP's process: 14/16711-6 - MicroRNAs and cell coupling interplay in the development, adaptation and degeneration of the nervous system
• Grantee: Alexandre Hiroaki Kihara
• Support Opportunities: Regular Research Grants