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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Casinga-cheirosa organic extract impairment over Balb-c male mice behavioral phenotype

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Author(s):
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Estork, Dirce M. [1] ; Gusmao, Daniela F. [1] ; Paciencia, Mateus L. B. [2, 3, 4] ; Frana, Sergio A. [2, 3, 4] ; Diaz, Ingrit E. C. [2, 3, 4] ; Varella, Antonio D. [2, 3, 4] ; Younes, Riad N. [2, 3, 4, 5] ; Reis, Luiz F. L. [6] ; Montero, Edna F. S. [7] ; Bernardi, Maria M. [1, 8] ; Suffredini, Ivana B. [1, 2, 3, 4, 8]
Total Authors: 11
Affiliation:
[1] Univ Estadual Paulista, Pesquisa & Posgrad, Programa Posgrad Patol Expt & Ambiental, Sao Paulo, SP - Brazil
[2] Univ Estadual Paulista, Lab Bot, Nucleo Pesquisas Biodiversidade, Sao Paulo, SP - Brazil
[3] Univ Estadual Paulista, Herbario UNIP, Sao Paulo, SP - Brazil
[4] Univ Estadual Paulista, Lab Extracao, Sao Paulo, SP - Brazil
[5] Hosp Sao Jose, Sao Paulo, SP - Brazil
[6] Hosp Sirio Libanes, Inst Ensino & Pesquisa, Sao Paulo, SP - Brazil
[7] Univ Sao Paulo, Fac Med, Sao Paulo, SP - Brazil
[8] Univ Estadual Paulista, Pesquisa & Posgrad, Programa Posgrad Odontol, Sao Paulo, SP - Brazil
Total Affiliations: 8
Document type: Journal article
Source: REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY; v. 26, n. 2, p. 216-224, MAR-APR 2016.
Web of Science Citations: 4
Abstract

ABSTRACT Laetia suaveolens (Poepp.) Benth., Salicaceae, popularly known as "casinga-cheirosa", "caferana", or "laranjinha", is native to Brazil but not endemic to this country. A crude organic extract was obtained from the leaves and stem and intraperitoneally administered in male Balb-c mice. Its behavioral effects were evaluated in the open field and elevated plus maze in a two-stage experiment that assessed ten different parameters related to behavior as locomotion, emotionality, and anxiety. In the first stage of the experiment, intraperitoneal the crude organic extract administration dose-dependently impaired locomotion and emotionality 30–120 min after administration. A significant decrease in defecation was observed, which was related to emotionality. No alterations in the elevated plus maze were found; thus, this apparatus was not used in the next stage of the experiment. In the second stage, the previously determined non-lethal dose of 0.1563 g/kg was intraperitoneally administered, which impaired locomotion and rearing frequency and increased immobility time. Necropsy revealed smooth intestine hemorrhage. Rutin, leucoside, nicotiflorin, guaijaverin, and astragalin were isolated from the crude organic extract. This is the first time that these compounds have been identified in L. suaveolens. In conclusion, the crude organic extract impaired locomotion and emotionality and caused hemorrhage in male Balb-c mice, indicating that its consumption can be harmful to humans and animals. The present results provide a basis for further studies on the pharmacology, toxicology, and natural product chemistry of the crude organic extract. (AU)