Microwave-assisted one-pot three-component synthesis of imine 1,2,3-triazoles

Full text
Author(s):	Souza, Frederico B. ^[1] ; Pimenta, Daniel C. ^[2] ; Stefani, Helio A. ^[1] Total Authors: 3
Affiliation:	^[1] Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Farm, Av Prof Lineu Prestes, 580 Bl 13 Sup, Sao Paulo, SP - Brazil ^[2] Inst Butantan, Sao Paulo, SP - Brazil Total Affiliations: 2
Document type:	Journal article
Source:	Tetrahedron Letters; v. 57, n. 14, p. 1592-1596, APR 6 2016.
Web of Science Citations:	7
Abstract
A general and efficient methodology for the synthesis of novel triazoles has been developed based on a microwave-assisted multicomponent reaction involving alpha-thio aldehyde and propargylamine, with the formation of an imine that in situ reacts with organoazides by copper-catalyzed {[}3+2] azides-alkyne cycloaddition (CuAAC). The reaction results in a small library of imine 1,4-disubstituted 1,2,3-triazoles. (C) 2016 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process:	13/20553-4 - Synthesis and functionalization of vinyl iodide sulfoxides
Grantee:	Frederico Bernardes de Souza
Support Opportunities:	Scholarships in Brazil - Doctorate (Direct)


FAPESP's process:	12/00424-2 - Synthesis of small libraries using potassium Organotrifluoroborates in Suzuki-Miyaura reactions
Grantee:	Helio Alexandre Stefani
Support Opportunities:	Research Projects - Thematic Grants