Striatal Dopamine Links Gastrointestinal Rerouting to Altered Sweet Appetite

Author(s):Show less -

Han, Wenfei ^{[1, 2, 3]} ; Tellez, Luis A. ^{[1, 2]} ; Niu, Jingjing ^{[1, 2, 4]} ; Medina, Sara ^[2] ; Ferreira, Tatiana L. ^{[1, 2, 5]} ; Zhang, Xiaobing ^[6] ; Su, Jiansheng ^[3] ; Tong, Jenny ^[4] ; Schwartz, Gary J. ^[7] ; van den Pol, Anthony ^[6] ; de Araujo, Ivan E. ^{[1, 2, 8]}

Affiliation

^[1] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06519 - USA

^[2] John B Pierce Fdn Lab, 290 Congress Ave, New Haven, CT 06519 - USA

^[3] Tongji Univ, Sch Stomatol, Lab Oral Biomed Sci & Translat Med, Shanghai 200072 - Peoples R China

^[4] Duke Univ, Med Ctr, Dept Med, Div Endocrinol, Durham, NC 27710 - USA

^[5] Fed Univ ABC, Math Comp & Cognit Ctr, BR-09210 Santo Andre - Brazil

^[6] Yale Univ, Sch Med, Dept Neurosurg, New Haven, CT 06519 - USA

^[7] Yeshiva Univ, Albert Einstein Coll Med, Bronx, NY 10461 - USA

^[8] Yale Univ, Sch Arts & Sci, Dept Physiol, New Haven, CT 06511 - USA

• Document type: Journal article
• Source: Cell Metabolism; v. 23, n. 1, p. 103-112, JAN 12 2016.
• Web of Science Citations: 29

Abstract

Reductions in calorie intake contribute significantly to the positive outcome of bariatric surgeries. However, the physiological mechanisms linking the rerouting of the gastrointestinal tract to reductions in sugar cravings remain uncertain. We show that a duodenal-jejunal bypass (DJB) intervention inhibits maladaptive sweet appetite by acting on dopamine-responsive striatal circuitries. DJB disrupted the ability of recurrent sugar exposure to promote sweet appetite in sated animals, thereby revealing a link between recurrent duodenal sugar influx and maladaptive sweet intake. Unlike ingestion of a low-calorie sweetener, ingestion of sugar was associated with significant dopamine effluxes in the dorsal striatum, with glucose infusions into the duodenum inducing greater striatal dopamine release than equivalent jejunal infusions. Consistently, optogenetic activation of dopamine-excitable cells of the dorsal striatum was sufficient to restore maladaptive sweet appetite in sated DJB mice. Our findings point to a causal link between striatal dopamine signaling and the outcomes of bariatric interventions. (AU)

• FAPESP's process: 13/09405-3 - Characterization of neural microcircuitry responsible for carbohydrates compulsions
• Grantee: Tatiana Lima Ferreira
• Support Opportunities: Scholarships abroad - Research