Post-Exercise Hypotension Is Mediated by a Decrease in Sympathetic Nerve Activity in Stages 2-3 CKD

Author(s)

Aprile, Daniele C. B. ^[1] ; Oneda, Bruna ^[1] ; Gusmao, Josiane L. ^[1] ; Costa, Luiz A. R. ^[2] ; Forjaz, Claudia L. M. ^[2] ; Mion, Jr., Decio ^[1] ; Tinucci, Tais ^{[2, 1]}

Affiliation

^[1] Univ Sao Paulo, Sch Med, Hosp Clin, Hypertens Unit, Nephrol Div, Gen Hosp, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Sch Phys Educ & Sport, Exercise Hemodynam Lab, Sao Paulo - Brazil

• Document type: Journal article
• Source: AMERICAN JOURNAL OF NEPHROLOGY; v. 43, n. 3, p. 206-212, 2016.
• Web of Science Citations: 5

Abstract

Background: This study aimed at evaluating the after effects of a single bout of aerobic exercise on muscle sympathetic nerve activity (MSNA), peripheral vascular resistance and blood pressure (BP) in stages 2-3 chronic kidney disease (CKD) patients. We hypothesized that CKD patients present a greater decline in these variables after the exercise than healthy individuals. Methods: Nine patients with stages 2-3 CKD (50 +/- 8 years) and 12 healthy volunteers (50 +/- 5 years) underwent 2 sessions, conducted in a random order: exercise (45 min, cycle ergometer, 50% of peak oxygen uptake) and rest (seated, 45 min). Sixty minutes after either intervention, MSNA (by microneurography), BP (by oscillometry), and forearm vascular resistance (FVR) were measured. A 2-way analysis of variance with group (between) and session (within) as main factors was employed, accepting p < 0.05 as significant. Results: Diastolic BP and MSNA were higher in the CKD than the control group in both sessions. Responses after exercise were similar in both groups. Systolic BP, diastolic BP, MSNA and FVR were significantly lower after the exercise than after the rest session in both the CKD and the control groups (162 +/- 15 vs. 152 +/- 23 and 155 +/- 11 vs. 145 +/- 16 mm Hg, 91 +/- 11 vs. 85 +/- 14 and 77 +/- 5 vs. 71 +/- 10 mm Hg, 38 +/- 4 vs. 31 +/- 4 and 34 +/- 2 vs. 27 +/- 4 burst/min, 59 +/- 29 vs. 41 +/- 29 and 45 +/- 20 vs. 31 +/- 8 U, respectively, all p < 0.05). Conclusion: These results showed that aerobic exercise may produce hemodynamic and neural responses that can be beneficial to these patients in spite of CKD. (C) 2016 S. Karger AG, Basel (AU)