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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Novel Double-Layered Conduit Containing Highly Bioactive Glass Fibers for Potential Nerve Guide Application

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Author(s):
Souza, Marina Trevelin [1, 2] ; Peitl, Oscar [1, 2] ; Zanotto, Edgar Dutra [1, 2] ; Boccaccini, Aldo R. [3]
Total Authors: 4
Affiliation:
[1] Univ Fed Sao Carlos, CeRTEV Ctr Res Technol & Educ Vitreous Mat, Rod Washington Luis, Km 235, BR-13565905 Sao Carlos, SP - Brazil
[2] Univ Fed Sao Carlos, Dept Mat Engn, Vitreous Mat Lab, Rod Washington Luis, Km 235, BR-13565905 Sao Carlos, SP - Brazil
[3] Univ Erlangen Nurnberg, Inst Biomat, D-91058 Erlangen - Germany
Total Affiliations: 3
Document type: Journal article
Source: INTERNATIONAL JOURNAL OF APPLIED GLASS SCIENCE; v. 7, n. 2, p. 183-194, JUN 2016.
Web of Science Citations: 6
Abstract

Peripheral nerve injuries are frequent conditions that currently have very few treatment alternatives. This study aimed to incorporate aligned bioactive glass microfibers (that belong to the SiO2-Na2O-K2O-MgO-CaO-P2O5 system) in nanofibrous poly epsilon-caprolactone (PCL) membranes to develop a new biocomposite that is potentially able to facilitate nerve growth and increase the polymer matrix's biological and mechanical properties. For the manufacture of this novel tubular nerve guide, electrospinning of PCL was performed on the surface of bioactive glass fibers, resulting in a two-layer microcomposite. The mechanical strength, bioactivity, wettability, degradation, and permeability of this new material were characterized. The preliminary results indicate that the incorporation of the bioactive glass fibers into PCL led to the development of a highly bioactive biocomposite with significantly improved mechanical properties and wettability compared with the PCL matrix alone. (AU)

FAPESP's process: 14/01726-8 - Development of biocomposites with bioactive glass fibers reinforcement for tissue engineering applications
Grantee:Marina Trevelin Souza
Support Opportunities: Scholarships abroad - Research Internship - Doctorate
FAPESP's process: 13/07793-6 - CEPIV - Center for Teaching, Research and Innovation in Glass
Grantee:Edgar Dutra Zanotto
Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC