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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Pretransplant beta(2)-Microglobulin Is Associated with the Risk of Acute Graft-versus-Host-Disease after Allogeneic Hematopoietic Cell Transplant

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Author(s):
Costa-Lima, Carolina [1, 2] ; Martins Miranda, Eliana Cristina [1] ; Colella, Marcos Paulo [1] ; Penteado Aranha, Francisco Jose [1] ; de Souza, Carmino Antonio [1, 2] ; Vigorito, Afonso Celso [1] ; De Paula, Erich Vinicius [1, 2]
Total Authors: 7
Affiliation:
[1] Univ Estadual Campinas, Hematol & Hemotherapy Ctr, BR-13083878 Campinas, SP - Brazil
[2] Univ Estadual Campinas, Fac Med Sci, Rua Tessalia Vieira de Camargo 126, BR-13083878 Campinas, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION; v. 22, n. 7, p. 1329-1332, JUL 2016.
Web of Science Citations: 1
Abstract

The risk of acute graft-versus-host disease (aGVHD) can be reliably estimated by the hematopoietic cell transplantation-specific comorbidity index (HCT-CI), which can be further refined by the incorporation of pre-hematopoietic cell transplantation (HCT) serum levels of inflammatory biomarkers such as ferritin and albumin. beta(2)-Microglobulin (beta(2)-m) is a key component of the MHC class I complex, which is independently associated with mortality and frailty in the general population. We took advantage of our institutional protocol that includes measurement of pre-HCT beta(2)-m serum levels in the most patients to investigate whether pre-transplant beta(2)-m levels were associated with the risk of aGVHD. One hundred three consecutive patients submitted to allogeneic HCT, of which 26 developed grades II to IV aGVHD, were included in the analysis. beta(2)-m was significantly associated with age and HCT-CI. Higher levels of beta(2)-m were observed in patients who developed aGVHD (P = .008). In the multivariate Cox regression model, beta(2)-m and HCT-CI remained independently associated with the risk of developing aGVHD. In conclusion, the association between beta(2)-m and the occurrence of aGVHD suggests that the measurement of this protein before HCT might represent an additional element for risk stratification of aGVHD. (C) 2016 American Society for Blood and Marrow Transplantation. (AU)

FAPESP's process: 13/09319-0 - Exploration of new mechanisms of epithelial barrier brekdown in acute gastrintestinal graft-versus-host-disease associated with alterations in "tight junctions"
Grantee:Erich Vinicius de Paula
Support Opportunities: Regular Research Grants