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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Self-regenerating and hybrid irreversible/reversible PDMS microfluidic devices

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Author(s):
Shiroma, Letcia S. [1] ; Piazzetta, Maria H. O. [1] ; Duarte-Junior, Gerson F. [2] ; Coltro, Wendell K. T. [2] ; Carrilho, Emanuel [3] ; Gobbi, Angelo L. [1] ; Lima, Renato S. [1]
Total Authors: 7
Affiliation:
[1] Ctr Nacl Pesquisa Energia & Mat, Lab Nacl Nanotecnol, Lab Microfabricacao, BR-13083970 Campinas, SP - Brazil
[2] Univ Fed Goias, Inst Quim, BR-74001970 Goiania, Go - Brazil
[3] Univ Sao Paulo, Inst Quim Sao Carlos, BR-13566590 Sao Carlos, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: SCIENTIFIC REPORTS; v. 6, MAY 16 2016.
Web of Science Citations: 17
Abstract

This paper outlines a straightforward, fast, and low-cost method to fabricate polydimethylsiloxane (PDMS) chips. Termed sandwich bonding (SWB), this method requires only a laboratory oven. Initially, SWB relies on the reversible bonding of a coverslip over PDMS channels. The coverslip is smaller than the substrate, leaving a border around the substrate exposed. Subsequently, a liquid composed of PDMS monomers and a curing agent is poured onto the structure. Finally, the cover is cured. We focused on PDMS/glass chips because of their key advantages in microfluidics. Despite its simplicity, this method created high-performance microfluidic channels. Such structures featured self-regeneration after leakages and hybrid irreversible/reversible behavior. The reversible nature was achieved by removing the cover of PDMS with acetone. Thus, the PDMS substrate and glass coverslip could be detached for reuse. These abilities are essential in the stages of research and development. Additionally, SWB avoids the use of surface oxidation, half-cured PDMS as an adhesive, and surface chemical modification. As a consequence, SWB allows surface modifications before the bonding, a long time for alignment, the enclosure of sub-micron channels, and the prototyping of hybrid devices. Here, the technique was successfully applied to bond PDMS to Au and Al. (AU)

FAPESP's process: 14/24126-6 - Microemulsification in Analytical Chemistry for the development of point-of-care platforms: study of intervening parameters and automation in microfluidics
Grantee:Renato Sousa Lima
Support Opportunities: Regular Research Grants