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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Comparative lung architecture of normal and by Duchenne Muscular Dystrophy affected mice

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Author(s):
Thais B. Lessa [1] ; Dilayla K. Abreu [2] ; Bruno M. Bertassoli [3] ; Carlos E. Ambrósio [4]
Total Authors: 4
Affiliation:
[1] Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootencia. Departamento de Cirurgia - Brasil
[2] Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootencia. Departamento de Cirurgia - Brasil
[3] Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Morfologia - Brasil
[4] USP. Faculdade de Zootecnia e Engenharia de Alimentos. Departamento de Medicina Veterinária - Brasil
Total Affiliations: 4
Document type: Journal article
Source: Pesquisa Veterinária Brasileira; v. 35, p. 56-60, 2015-12-00.
Abstract

Abstract: The Duchenne Muscular Dystrophy (DMD) is a recessive genetic disease characterized by progressive muscle weakness of the pelvic and scapular girdle and progressing to respiratory or heart failure. The mdx mouse is a model widely used for studies. Although they possess a milder phenotype, the morphology and biochemistry of the diaphragm are similar to human DMD. We performed a descriptive anatomical study of the pulmonary parenchyma of five mdx animal models and compared these with the lungs of 5 mice BALB/C57 (Mus musculus). The findings suggest that the mdx model has morphological features similar to BALB/C57 mice and it must be used with caution in clinical trials which involve the lung. (AU)

FAPESP's process: 12/04506-3 - COMPARATIVE STUDY OF CONTRACTILITY AND PASSIVE PROPERTIES OF THE MDX DIAPHRAGM IN DIFFERENT AGES
Grantee:Thais Borges Lessa
Support Opportunities: Scholarships in Brazil - Doctorate